铁死亡的发生机制在内异症及其他疾病中的研究进展  

RESEARCH PROGRESS ON THE MECHANISM OF FERROPTOSIS IN ENDOMETRIOSIS AND OTHER DISEASES

作　　者：红霞[1] 周建星 托娅[2] Hongxia;ZHOU Jianxing;Tuoya(College of Primary Clinical Medicine,Inner Mongolia Medical University,Hohhot 010059,China;Repraductive Medicine Center,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院生殖医学中心,内蒙古呼和浩特010050

出　　处：《内蒙古医科大学学报》2025年第1期104-108,共5页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区重点研发和成果转化计划项目(2023YFSH0011);内蒙古自治区高等学校青年科技英才支持计划项目(NJYT22006);内蒙古自治区自然科学基金项目(2019MS08132);内蒙古医科大学附属医院博士启动基金项目(NYFY BS202137)。

摘　　要：铁死亡(Ferroptosis)是一种新型的、铁依赖性的细胞死亡方式,它在特性上与目前普遍认可的细胞凋亡和坏死有很大的区别。这种死亡方式是活性氧(reactive oxygen species,ROS)的蓄积和脂质过氧化导致的。近年来,探讨Ferroptosis在各类疾病中的调控作用的研究成为科研热点。因此本文从铁代谢、脂质代谢、抗氧化系统代谢和巨噬细胞四个方面分析了Ferroptosis的发生机制,并进一步探讨Ferroptosis机制在子宫内膜异位症、肿瘤、神经退行性疾病和心肌缺血-再灌注损伤中的研究进展,为今后的诊断和治疗提供新的思路。Ferroptosis is a novel,iron-dependent cell death mode,which is quite different in character from the currently accepted apoptosis and necrosis.This mode of death is caused by the accumulation of reactive oxygen species(ROS)and lipid peroxidation.In recent years,theories about the regulatory role of ferroptosis in various diseases have been complicated.Therefore,this paper analyzed the mechanism of ferroptosis from three aspects:iron metabolism,lipid metabolism and antioxidant system metabolism,and further discussed the research progress of ferroptosis mechanism in tumor,neurodegenerative diseases,myocardial ischemia-reperfusion injury and endometriosis,providing new ideas for future diagnosis and treatment.

关 键 词：铁死亡 发生机制 研究进展 

分 类 号：R363[医药卫生—病理学]