乳腺癌首发单纯骨转移的临床病理特点及预后影响因素分析  

Clinicopathologic characteristics and influencing factors of prognosis of first-episode bone-only metastasis of breast cancer

作　　者：李苗苗 唐晓梅[2] Li Miaomiao;Tang Xiaomei(Department of Pathology,Baoji High-Tech Hospital,Baoji 72100,China;Department of Pathology,Baoji People’s Hospital,Baoji 721000,China)

机构地区：[1]宝鸡高新医院病理科,宝鸡721000 [2]宝鸡市人民医院病理科,宝鸡721000

出　　处：《中国实用医刊》2025年第3期21-25,共5页Chinese Journal of Practical Medicine

摘　　要：目的探讨乳腺癌首发单纯骨转移(BOM)的临床病理特点及预后影响因素。方法抽取2013年1月至2021年12月宝鸡高新医院收治的90例乳腺癌首发BOM患者为研究组,另抽取同期收治的300例非乳腺癌首发BOM患者为对照组。回顾性分析两组的临床资料,明确乳腺癌首发BOM患者的病理特点,采用单因素及Cox检验分析预后影响因素。结果研究组中位无进展生存时间为19.65个月,激素受体阳性患者占比为82.22%(74/90);对照组中位无进展生存时间为9.87个月,激素受体阳性患者占比为64.33%(193/300)。研究组中位生存总时间为46.32个月。单因素分析结果显示,激素受体状态、骨转移位置、骨转移数量及治疗方案为乳腺癌首发BOM患者的独立影响因素(P<0.05)。Cox检验结果显示,骨转移数量以及内分泌治疗是影响研究组激素受体阳性患者预后的主要因素(P<0.05);该类患者的预后多以内分泌治疗或者综合治疗方案为主,效果优于单独采取化疗干预方案(P<0.05);乳腺癌多部位骨转移BOM患者则多采取联合治疗方案,其治疗结果优于内分泌治疗或者单独化疗(P<0.05)。结论乳腺癌首发BOM患者预后与激素受体情况、骨转移位置、骨转移数量及治疗方案存在密切关联性。针对乳腺癌首发BOM患者的临床情况预后多以内分泌治疗为主,乳腺癌多部位骨转移BOM患者则需考虑采取联合治疗方案。Objective To investigate the clinicopathologic characteristics and influencing factors of prognosis of first-episode bone-only metastasis(BOM)of breast cancer.MethodsNinety patients with the first-episode BOM of breast cancer admitted to Baoji High-Tech Hospital from January 2013 to December 2021 were selected as the study group.And 300 patients with the first-episode BOM of non-breast cancer were selected as the control group.The clinical data of the two groups were retrospectively analyzed to clarify the pathological characteristics of patients with the first-episode BOM of breast cancer,and influencing factors of prognosis were analyzed by univariate analysis and Cox test.ResultsThe median progression-free survival time in the study group was 19.65 months,and the proportion of hormone receptor-positive patients was 82.22%(74/90).The median progression-free survival time in the control group was 9.87 months,and the proportion of hormone receptor-positive patients was 64.33%(193/300).The median total survival time in the study group was 46.32 months.Results of univariate analysis revealed that hormone receptor status,metastasis location,number of bone metastases,and treatment regimen were all independent influencing factors for patients with first-episode BOM of breast cancer(P<0.05).Cox test revealed that number of bone metastases and endocrine therapy were the main influencing factors for the prognosis of hormone receptor-positive patients in the study group(P<0.05).The prognosis of these patients was mainly endocrine therapy or comprehensive treatment regimen,and the effect was better than chemotherapy intervention alone(P<0.05).Most patients with multi-site BOM of breast cancer were treated by combined therapy,and the treatment outcome was better than endocrine therapy or chemotherapy alone(P<0.05).ConclusionsThe prognosis of patients with the first-episode BOM of breast cancer has close correlations with the status of hormone receptors,the location of bone metastasis,the number of bone metastases and the tr

关 键 词：乳腺癌 单纯骨转移 临床病理特点 预后 

分 类 号：R737.9[医药卫生—肿瘤]