乳腺癌脑转移机制  

Mechanism of breast cancer brain metastasis

作　　者：周剑锋 李家伟 郭建冉 褚苗苗 李敏[2] 付波 ZHOU Jianfeng;LI Jiawei;GUO Jianran;CHU Miaomiao;LI Min;FU Bo(School of Medical Laboratory,Shandong Second Medical University,Weifang 216000,China;Department of Precision Biomedical Key Laboratory,Liaocheng People's Hospital,Shandong Provincial Key Laboratory of Medical and Health Aging Intervention and Active Health Precision Medicine,Liaocheng 252000,China)

机构地区：[1]山东第二医科大学医学检验学院,潍坊261000 [2]聊城市人民医院精准生物医学重点实验室,山东省医药卫生衰老干预与主动健康精准医学重点实验室,聊城252000

出　　处：《生命的化学》2025年第3期461-469,共9页Chemistry of Life

基　　金：山东省自然科学基金项目(ZR2022MH272);山东第二医科大学科技发展项目(2023FYM106,2023FYQ035);山东省中医药科技项目(M-2022122);聊城市人民医院院级青年科研基金资助项目(LYQN201910)。

摘　　要：乳腺癌是女性癌症相关死亡的首要原因,10%~15%的乳腺癌患者会发生脑转移。发生脑转移的乳腺癌患者,其5年生存率会显著降低。已知的乳腺癌脑转移步骤包括:上皮-间充质的转化、内渗,启动大脑转移的生态位,突破血脑屏障和在脑内定植形成转移灶。本文以乳腺癌脑转移的步骤为主线阐明其机制研究进展,以期为乳腺癌脑转移的临床诊治提供新的视角与策略。Breast cancer is the leading cause of cancer-related death in women,and about 10%to 15%of breast cancer patients will have brain metastasis.The 5-year survival rate of breast cancer patients with brain metastasis will be significantly reduced.It is known that the brain metastasis steps of breast cancer include:transformation of epithelial mesenchyme,infiltration,starting the niche of brain metastasis,breaking the blood-brain barrier and colonizing in the brain to form a metastatic focus.This review takes the steps of brain metastasis of breast cancer as the main line to clarify its mechanism research progress,in order to provide a new perspective and strategy for the clinical diagnosis and treatment of brain metastasis of breast cancer.

关 键 词：乳腺癌脑转移 血脑屏障 分子机制 免疫疗法 

分 类 号：R737.9[医药卫生—肿瘤]