膜联蛋白A2在肝脏生理与病理学中的作用  

Roles of annexin A2 on liver physiology and pathology

作　　者：高宇暄 孔宪明 GAO Yuxuan;KONG Xianming(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Medical Sciences Research Center,Renji Hospital,Shanghai 200127,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]仁济医院医学研究中心,上海200127

出　　处：《生命的化学》2025年第3期470-479,共10页Chemistry of Life

摘　　要：膜联蛋白A2(annexin A2,ANXA2)是一种钙依赖性磷脂结合蛋白,在细胞膜稳定、信号传导和细胞骨架重组等方面发挥关键作用。近年来,ANXA2在肝脏疾病中的多重功能备受关注,其在非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)和肝纤维化中的作用涉及氧化应激和炎症反应的调控,并在肝脏再生与组织修复中具有潜在价值。此外,研究表明,ANXA2在肝细胞癌(hepatocellular carcinoma,HCC)中高表达,促进肿瘤进展并与患者不良预后密切相关,具有作为早期诊断标志物和治疗靶点的潜力。本文系统综述了ANXA2在肝脏生理与病理过程中的多重作用,重点探讨其在NAFLD、肝纤维化和HCC中的分子机制,并概述其在疾病诊断、治疗及预后评估中的临床应用前景,以期为肝脏疾病的基础研究和临床转化提供新思路。Annexin A2(ANXA2)is a calcium-dependent phospholipid-binding protein which plays a crucial role in membrane stabilization,signal transduction,and cytoskeletal reorganization.In recent years,the multifaceted roles of ANXA2 in liver diseases have attracted significant attention.Its involvement in nonalcoholic fatty liver disease(NAFLD)and liver fibrosis includes the regulation of oxidative stress and inflammatory responses,underscoring its potential in liver regeneration and tissue repair.Furthermore,studies have shown that ANXA2 is highly expressed in hepatocellular carcinoma(HCC),where it promotes tumor progression and is closely linked to poor patient prognosis,indicating its potential as an early diagnostic biomarker and therapeutic target.This review systematically examines the diverse roles of ANXA2 in liver physiology and pathology,focusing on its molecular mechanisms in NAFLD,liver fibrosis,and HCC.Additionally,it summarizes the clinical prospects of ANXA2 in disease diagnosis,treatment,and prognosis assessment,aiming to provide new insights for basic research and clinical application in liver diseases.

关 键 词：膜联蛋白A2 肝细胞脏 肝癌 信号传导 

分 类 号：R575[医药卫生—消化系统]