结直肠癌肝转移研究模型的现状及展望  

Current situation and prospect of liver metastasis research model for colorectal cancer

作　　者：袁佳莹 范小彧 费博 喻春钊 Jiaying Yuan;Xiaoyu Fan;Bo Fei;Chunzhao Yu(Department of General Surgery,Sir Run Run Hospital,Nanjing Medical University,Nanjing 211112,China;Department of General Surgery,Nantong Tongzhou People's Hospital,Nantong 226300,China;Department of General Surgery,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China)

机构地区：[1]南京医科大学附属逸夫医院普外科,211112 [2]南通市通州区人民医院普通外科,226300 [3]南京医科大学第二附属医院普外科,210011

出　　处：《中华结直肠疾病电子杂志》2025年第1期40-46,共7页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：国家自然科学基金面上项目(No.82373293);国家重点研发计划(No.2018YFE0127300);江苏省卫生健康委员会研究项目(No.ZD2022063);江苏省“333工程培养资金”项目(No.BRA2020091);江苏省科技计划重点项目(No.BE2019759)。

摘　　要：结直肠癌肝转移(CRLM)是结直肠癌患者最主要的死亡原因之一,其严重威胁着人民群众的生命安全,阻碍了社会经济的繁荣发展。随着我国结直肠癌发病率逐年增加,CRLM的危害也日益突显。在这样的背景下,如何科学有效的建立CRLM模型,以促进对肿瘤侵袭转移过程的深入了解,揭示相应机制,评估不同诊疗方案的效果,最终实现CRLM的早期防诊治应是当前研究的重点和难点。传统的CRLM模型包括致癌物诱导模型、原位种植模型、异位种植模型、异种移植模型及基因工程小鼠模型。近年来随着科学技术的不断进步,新的造模方法如微流控芯片模型等不断涌现,提供了更多、更新的选择。本文回顾了国内外相关文献,对传统小鼠模型和新兴造模方法进行深入探讨,旨在比较各造模方法的优缺点并介绍最新研究成果,为CRLM模型的科学建立提供一定指导,最终为CRLM患者带来更科学的个性化治疗。Colorectal cancer liver metastasis(CRLM)is the most important cause of death in colorectal cancer patients,which seriously threatens the life safety of people and hinders the prosperity and development of society and economy.With the increasing incidence of colorectal cancer in our country,the harm of CRLM is becoming more and more obvious.In this context,how to establish a scientific and effective CRLM model to promote the in-depth understanding of the tumor invasion and metastasis process,reveal the corresponding mechanism,evaluate the effect of different diagnosis and treatment schemes,and finally realize the early prevention and treatment of CRLM should be the focus and difficulty of current research.Traditional CRLM models include carcinogen induction model,orthotopic model,heterotopic model,xenogenic implantation model and genetically engineered mouse model.In recent years,with the continuous progress of science and technology,new modeling methods such as microfluidic chip model have emerged,providing more updating options.In this paper,relevant literature at home and abroad was reviewed,and the advantages and disadvantages of traditional mouse models and emerging modeling methods were discussed in depth,aiming to compare the advantages and disadvantages of each modeling method and introduce the latest research results,so as to provide certain guidance for the scientific establishment of CRLM model and ultimately bring more scientific personalized treatment for CRLM patients.

关 键 词：结直肠肿瘤 肝转移 动物模型 微流控模型 

分 类 号：R735.3[医药卫生—肿瘤]