杜仲叶中重金属污染分析  

Analysis of Heavy Metal Pollution in Duzhong(Eucommia Ulmoides)Leaves

作　　者：匡创富[1,2] 张年 梁雪娟 龚年春[2] 王艾琳 刘小丽 彭艳梅[2] KUANG Chuangfu;ZHANG Nian;LIANG Xuejuan;GONG Nianchun;WANG Ailin;LIU Xiaoli;PENG Yanmei(The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha Hunan 410005,China;Hunan Academy of Chinese Medicine,Changsha Hunan 410006,China;The First Hospital of Hunan University of Chinese Medicine,Changsha Hunan 410007,China)

机构地区：[1]湖南中医药大学第二附属医院,湖南长沙410005 [2]湖南省中医药研究院,湖南长沙410006 [3]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中医药导报》2025年第3期89-94,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(81903746);湖南省重点研发计划项目(2021SK2007);湖南省中医药科研计划重点项目(A2023005);国家卫生健康委员会食品安全标准与监测评估司食药物质试点工作转归政策研究项目。

摘　　要：目的:测定湖南省内不同地区杜仲叶中重金属含量,并对其进行健康风险评估,为杜仲叶的质量控制提供参考。方法:参考2020年版《中华人民共和国药典》方法测定杜仲叶样品中重金属含量,利用每日最大可耐受摄入量(EDI)、靶标危害系数(THQ)和致癌风险(CR)评估模型进行健康风险评估,同时考察杜仲叶中重金属与产地土壤中重金属之间的关系。结果:30批杜仲叶中有1批样品的铅含量不符合《中华人民共和国药典》的限量标准。杜仲叶中镉和铅元素的富集与土壤中镉和铅元素有一定的相关性。EDI和CR的结果未发现明显健康风险,THQ结果显示有10批杜仲叶存在潜在健康风险。结论:杜仲叶基本上符合限量标准,但个别产地杜仲叶重金属存在污染情况,应针对性进行重金属污染治理,以保证杜仲叶的用药安全。Objective:To determine the heavy metal content in Duzhong(Eucommia ulmoides)leaves from different regions in Hunan Province and conduct a health risk assessment,providing a reference for the quality control of Duzhong(Eucommia ulmoides)leaves.Methods:The heavy metal content in Duzhong(Eucommia ulmoides)leaf samples were measured according to the 2020 edition of the Pharmacopoeia of the People's Republic of China.Health risk assessment was performed using the estimated daily intake(EDI),target hazard quotient(THQ),and carcinogenic risk(CR)models.The relationship between heavy metals in Duzhong(Eucommia ulmoides)leaves and those in the soil of their production areas were also investigated.Results:Among 30 batches of Duzhong(Eucommia ulmoides)leaves,the lead content in one batch did not meet the limit standards specified in the Pharmacopoeia of the People's Republic of China.The enrichment of cadmium and lead in Duzhong(Eucommia ulmoides)leaves showed some correlation with the cadmium and lead content in the soil.The EDI and CR results indicated no significant health risks,while the THQ results suggested potential health risks in 10 batches of Duzhong(Eucommia ulmoides)leaves.Conclusion:Duzhong(Eucommia)ulmoides leaves generally comply with the limit standards,however,certain production areas exhibit contamination with heavy metals.Targeted heavy metal pollution control measures should be implemented to ensure the safety of Duzhong(Eucommia ulmoides)leaves for medicinal use.

关 键 词：杜仲叶 食药物质 重金属 健康风险评估 

分 类 号：R284.1[医药卫生—中药学]