阿魏酸治疗阿尔茨海默病的药理机制研究进展  

Research Progress on Pharmacological Mechanism of Ferulic Acid in the Treatment of Alzheimer's Disease

作　　者：景晚霞 李玲 田心 郝文韬 邬尚志 JING Wanxia;LI Ling;TIAN Xin;HAO Wentao;WU Shangzhi(The First Clinical School of Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712000,China;Shaanxi Provincial Hospital of Chinese Medicine,Xi'an Shaanxi 710000,China)

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712000 [2]陕西省中医医院,陕西西安710000

出　　处：《中医药导报》2025年第3期133-140,共8页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点研发计划项目(2018YFC2002500);2023年国家中医药管理局老年病重点科室建设项目。

摘　　要：阿尔茨海默病(AD)是一种好发于老年人的慢性进行性中枢神经系统退行性疾病,发病机制复杂,现有的治疗策略只能缓解症状,不能有效治愈此病。天然化合物具有易得、来源广、毒副作用小等特点,已成为研究者的研究热点。总结近年来国内外文献,发现当归有效成分阿魏酸(FA)作为一种的天然化合物,可以通过多种机制,包括抑制Aβ聚集、抗氧化应激、抗炎、调节Tau蛋白磷酸化、抗细胞凋亡、抑制胆碱酯酶活性、调节线粒体动力学及功能障碍、调节肠道菌群、调节胰岛素抵抗、改善脑部微循环障碍及抑制细胞内钙超载等,综合干预AD的病理过程,在AD的治疗中显示出巨大的潜力。Alzheimer's disease(AD)is a chronic progressive degenerative disease of the central nervous system that occurs in the elderly.The pathogenesis is complex.Existing treatment strategies can only alleviate symptoms and cannot effectively cure the disease.Natural compounds have the characteristics of easy availability,wide source,and small side effects.They have become a research hotspot for researchers.By summarizing the literature at home and abroad in recent years,the author has found that ferulic acid(FA),an active ingredient of Danggui(Angelica sinensis),can be used as a natural compound.Through a variety of mechanisms,including inhibition of Aβaggregation,anti-oxidative stress,anti-inflammation,regulation of Tau protein phosphorylation,anti-apoptosis,inhibition of cholinesterase activity,regulation of mitochondrial dynamics and dysfunction,regulation of intestinal flora,inhibition of the reduction of capillary density and diameter in the hippo-campus,and other comprehensive intervention in the pathological process of AD,it shows great potential in the treatment of AD.

关 键 词：阿尔茨海默病 有效成分 阿魏酸 研究进展 靶向治疗 

分 类 号：R285.5[医药卫生—中药学]