直肠腺癌患者术后COX-2以及Ki67的表达与术后复发风险的关联性  

Correlation Between the Expression of COX-2 and Ki67 and the Risk of Postoperative Recurrence in Colorectal Adenocarcinoma Patients

作　　者：王晗 吴坤[1] 韩月蕊[1] WANG Han;WU Kun;HAN Yuerui(Nanyang Central Hospital,Nanyang,473000)

机构地区：[1]河南省南阳市中心医院,473000

出　　处：《实用癌症杂志》2025年第4期615-618,共4页The Practical Journal of Cancer

摘　　要：目的分析直肠腺癌患者术后环氧合酶-2(Cycloxygenase-2,COX-2)和肿瘤增殖抗原(Ki67)的表达与术后复发风险的关联性。方法回顾性分析92例接受根治术治疗的直肠腺癌患者的临床资料,根据术后3个月是否复发,分为复发组和未复发组。检测2组患者COX-2、Ki67,并进行对比,对影响直肠腺癌患者术后复发的相关因素进行Cox回归分析。绘制受试者工作特征ROC,分析COX-2和Ki67对直肠腺癌患者术后复发的预测价值。结果术后及随访时未复发组的COX-2和Ki67水平均明显低于复发组(P<0.05)。2组临床分期、淋巴结转移、分化程度及术后COX-2和Ki67对比,差异有统计学意义(P<0.05);Cox回归分析显示,临床分期、肿瘤分化程度和淋巴结转移、COX-2阳性和Ki67≥14%均是直肠腺癌术后复发的危险因素(P<0.05)。术后离院时的COX-2和Ki67预测复发的AUC分别0.765和0.871,均有一定预测价值。结论直肠腺癌患者术后COX-2和Ki67阳性与肿瘤复发有关,可用于预测复发风险。Objective To analyze the association between the expression of Cycloxygenase-2(COX-2)and tumor proliferation antigen(Ki67)and the risk of postoperative recurrence in patients with rectal adenocarcinoma.Methods The clinical data of 92 patients with rectal adenocarcinoma who received radical surgery were retrospectively analyzed.According to whether the patients recurred 3 months after surgery,they were divided into recurrence group and non-recurrence group.COX-2 and Ki67 of the 2 groups were detected and compared,and Cox regression analysis was performed on the related factors affecting the postoperative recurrence of rectal adenocarcinoma patients.Receiver operating characteristic ROC was plotted to analyze the predictive value of COX-2 and Ki67 for postoperative recurrence in colorectal adenocarcinoma patients.Results The COX-2 and Ki67 levels in the non-recurrence group were significantly lower than those in the recurrence group after surgery and during follow-up(P<0.05).There were significant differences in clinical stage,lymph node metastasis,differentiation degree,COX-2 and Ki67 between the 2 groups(P<0.05).COX regression analysis showed that clinical stage,tumor differentiation degree,lymph node metastasis,COX-2 positive and Ki67≥14%were the influential factors for postoperative recurrence of colorectal adenocarcinoma(P<0.05).The AUC of COX-2 and Ki67 for postoperative recurrence was 0.765 and 0.871 respectively,both of which had certain predictive value.Conclusion Positive COX-2 and Ki67 are associated with tumor recurrence in colorectal adenocarcinoma patients after surgery,and both can be used to predict the risk of recurrence.

关 键 词：直肠腺癌 COX-2 KI67 复发 风险 

分 类 号：R735.37[医药卫生—肿瘤]