血清miR-618、miR-144表达与直肠癌患者腹腔镜根治术后复发的关系  

The Relationship Between Serum miR-618 and miR-144 Expression and Postoperative Recurrence in Rectal Cancer Patients Underwent Laparoscopic Radical Surgery

作　　者：李辰[1] 何新立[1] 叶鹏飞 席岚岚 张乐乐[1] 赵文召[1] 孔金玉 LI Chen;HE Xinli;YE Pengfei(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471000)

机构地区：[1]河南科技大学第一附属医院,471000 [2]河南省肿瘤表观遗传重点实验室,河南科技大学分子实验室,471000

出　　处：《实用癌症杂志》2025年第4期619-623,632,共6页The Practical Journal of Cancer

摘　　要：目的探讨血清微小RNA(miR)-618、miR-144表达与直肠癌患者腹腔镜根治术后复发的关系。方法回顾性分析92例直肠癌患者资料。记录患者3年随访期间的复发情况,将患者分为未复发组和复发组,分析血清miR-618、miR-144表达与直肠癌患者腹腔镜根治术后复发的关系。结果全部92例患者均完成随访,有28例患者在随访期间复发,复发率为30.43%(28/93),中位复发时间为15(12.00,20.00)个月。相较于未复发组,复发组中低分化占比较高,CEA、CA19-9水平较高,miR-618、miR-144水平较低(P<0.05)。经Cox回归分析,CEA、CA19-9是直肠癌腹腔镜根治术复发的危险因素(P<0.05),miR-618、miR-144是患者术后复发的保护因素(P<0.05)。血清miR-618、miR-144水平均低表达时,直肠癌患者腹腔镜根治术后复发概率是血清miR-618、miR-144水平均高表达时的15倍,协同效应为两者单独存在产生效应之和的3.17倍(SI=3.17)。结论血清miR-618、miR-144在直肠癌中表达下调,其低表达可能提示直肠癌患者腹腔镜根治术后复发风险,且二者对直肠癌腹腔镜根治术后复发存在交互作用。Objective To explore the relationship between the expression of serum microRNA-618 and miR-144 and postoperative recurrence in patients with rectal cancer underwent laparoscopic radical surgery.Methods A retrospective analysis was conducted on the data of 92 rectal cancer patients.The recurrence of the patients during the 3-year follow-up period was recorded.The patients were divided into non recurrence group and recurrence group according to the recurrence.The relationship between the expression of serum miR-618 and miR-144 and the recurrence of rectal cancer patients after laparoscopic radical resection was analyzed.Results All 92 patients completed follow-up,with 28 patients experiencing recurrence during the follow-up period,with a recurrence rate of 30.43%(28/93)and a median recurrence time of 15(12.00,20.00)months.Compared to the non recurrence group,the recurrence group had a higher proportion of low differentiation,higher levels of CEA and CA19-9,and lower levels of miR-618 and miR-144(P<0.05).According to Cox regression analysis,CEA and CA19-9 were risk factors for recurrence of laparoscopic radical resection of rectal cancer(P<0.05),while miR-618 and miR-144 were protective factors for postoperative recurrence in patients(P<0.05).When the serum levels of miR-618 and miR-144 were both low,the probability of recurrence in rectal cancer patients undergoing laparoscopic radical surgery was 15 times higher than when the serum levels of miR-618 and miR-144 are both high and low,and the synergistic effect was 3.17 times the sum of the effects produced by the 2 alone(SI=3.17).Conclusion Serum miR-618 and miR-144 are downregulated in rectal cancer,and their low expression may indicate the risk of recurrence after laparoscopic radical surgery in rectal cancer patients,and the 2 have an interactive effect on the recurrence of rectal cancer after laparoscopic radical surgery.

关 键 词：直肠癌 腹腔镜根治术 血清miR-618 miR-144 复发 交互作用 

分 类 号：R735.37[医药卫生—肿瘤]