富马酸伏诺拉生片对难治性幽门螺杆菌感染合并慢性胃炎患者血清胃肠激素及炎症指标的影响  

Effects of Vonoprazan Fumarate Tablet on Serum Gastrointestinal Hormones and Inflammatory Indices in Patients with Refractory Helicobacter Pylori Infection Complicated with Chronic Gastritis

作　　者：韩莉[1] 刘静[1] HAN Li;LIU Jing(Department of Gastroenterology,Zhengzhou People's Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州人民医院消化内科,郑州450000

出　　处：《中国合理用药探索》2025年第3期94-98,共5页Chinese Journal of Rational Drug Use

基　　金：河南省医学科技攻关计划项目(SBGJ202002025)。

摘　　要：目的:探讨富马酸伏诺拉生片对难治性幽门螺杆菌(Hp)感染合并慢性胃炎患者血清胃肠激素及炎症指标的影响。方法:对2021年12月~2022年12月某院难治性Hp感染合并慢性胃炎的109例患者进行随机分配入组,分为观察组(n=55)和对照组(n=54)。对照组给予含艾司奥美拉唑镁的四联方案治疗,观察组给予含富马酸伏诺拉生片的四联方案治疗,比较两组患者胃泌素(GAS)、胃动素(MTL),肿瘤坏死因子(TNF)-α、白介素IL-6(IL-6)和白介素-8(IL-8)水平,临床疗效及不良反应情况。结果:治疗后,两组患者GAS和MTL水平均升高,TNF-α、IL-6和IL-8水平均下降,且观察组低于对照组(P<0.05)。观察组根除率(81.82%)高于对照组(64.81%,P<0.05),临床治疗总有效率(98.18%)高于对照组(77.78%,P<0.05)。结论:富马酸伏诺拉生片能够有效提升难治性Hp感染的根除率,改善患者的GAS和MTL水平,降低机体的炎症反应,减轻患者临床症状。Objective:To investigate the effects of fumarate on serum gastrointestinal hormones and inflammatory indices in patients with refractory Helicobacter pylori(Hp)infection complicated with chronic gastritis.Methods:109 chronic gastritis patients who received treatment for refractory Hp infection in a certain hospital from December 2021 to December 2022,were randomly assigned to an observation group(55 patients)or the control group(54 patients)using allocation concealment.Patients in the control group received a quadruple regimen containing esomeprazole magnesium,while the patients in the observation group were treated with a quadruple regimen containing vonoprazan fumarate tablet.The clinical effects of both groups were compared,and the levels of gastrin(GAS),motilin(MTL),tumor necrosis factors(TNF-α),serum interleukin-6(IL-6),interleukin-8(IL-8),and adverse events were also measured.Results:After treatment,the levels of GAS and MTL increased in both patient groups,while the levels of TNF-α,IL-6,and IL-8 decreased on average.Notably,the changes observed in the observation group were significantly lower than those in the control group(P<0.05).The eradication rate in the observation group(81.82%)was significantly higher than that in the control group(64.81%),and the total effective rate of clinical treatment was also higher in the observation group(98.18%)compared to the control group(77.78%,P<0.05).Conclusion:Fumarate can effectively enhances the eradication rate of refractory Hp infection,improve the levels of GAS and MTL,and reduces inflammatory responses,and alleviates the clinical symptoms.

关 键 词：富马酸伏诺拉生片 幽门螺杆菌 慢性胃炎 血清胃肠激素 炎症指标 

分 类 号：R571[医药卫生—消化系统]