肺部肿瘤射频消融对患者外周血T细胞亚群的影响  

The Effect of Radiofrequency Ablation of Lung Tumors on Peripheral Blood T Cell Subsets in Patients

作　　者：刘峰[1] 乔元勋 LIU Feng;QIAO Yuanxun(Department of Oncology,Tai'an Traditional Chinese Medicine Hospital,Tai'an 271000,Shandong,China)

机构地区：[1]泰安市中医医院肿瘤科,山东泰安271000

出　　处：《世界复合医学(中英文)》2025年第1期162-164,168,共4页World Journal of Complex Medicine

摘　　要：目的分析肺部肿瘤射频消融对患者外周血T细胞亚群的影响。方法选择2022年1月—2023年11月泰安市中医医院行射频消融的120例肺部肿瘤患者,以治疗方法的不同分为两组,各60例。对照组行放化疗治疗,观察组在此基础上行射频消融治疗,分析两组临床疗效、外周血T细胞亚群变化情况以及并发症发生情况。结果观察组治疗总有效率为75.00%(45/60)比对照组的55.00%(33/60)高,差异有统计学意义(χ^(2)=5.275,P<0.05)。治疗前,两组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比较,差异均无统计学意义(P均>0.05),治疗后,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,CD8^(+)低于对照组,差异均有统计学意义(P<0.05)。两组白细胞减少、血小板降低、消化道症状及肝肾功能障碍等并发症发生率比较,差异均无统计学意义(P均>0.05)。结论射频消融对肺部肿瘤疗效较好,可调节肺部肿瘤患者T细胞亚群水平,改善患者免疫抑制状态。Objective To analyze the effects of radiofrequency ablation of lung tumors on peripheral blood T cell subsets.Methods A total of 120 patients with lung tumor who underwent radiofrequency ablation in Tai'an Traditional Chinese Medicine Hospital from January 2022 to November 2023 were selected and divided into two groups,with 60 cases in each group according to different treatment methods.The control group was treated with radiotherapy and chemotherapy,and the observation group was treated with radiofrequency ablation on this basis.The clinical efficacy,changes of peripheral blood T cell subsets and complications of the two groups were analyzed.Results The total effective rate of treatment in the observation group was 75.00%(45/60),which was higher than 55.00%(33/60)in the control group,and the difference was statistically significant(χ^(2)=5.275,P<0.05).Comparison of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)in the two groups before treatment,there were no statistically significant differences(P>0.05).After treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and CD8^(+)was lower than that in the control group,and the differences were statistically significant(all P<0.05).Compared the incidence of leukopenia,thrombocytopenia,digestive tract symptoms and liver and kidney dysfunction,there were no statistically significant differences(all P>0.05).Conclusion Radiofrequency ablation has a good effect on lung tumors.It can adjust the level of T cell subsets and improve the immunosuppressive state of patients with lung tumors.

关 键 词：肺部肿瘤 射频消融 外周血T细胞亚群 

分 类 号：R734.2[医药卫生—肿瘤]