神经节苷脂在急性缺血性脑卒中静脉溶栓治疗中的应用效果及对脑血流灌注的影响  

Application effect of ganglioside in intravenous thrombolytic therapy for acute ischemic stroke and its influence on cerebral blood perfusion

作　　者：崔静雪 任凤勤 CUI Jingxue;REN Fengqin(Neurology Department,Xi'an Gaoxin Hospital,Xi'an 710000,China)

机构地区：[1]西安高新医院神经内科,陕西西安710000

出　　处：《临床医学研究与实践》2025年第10期54-57,共4页Clinical Research and Practice

摘　　要：目的探讨神经节苷脂在急性缺血性脑卒中静脉溶栓治疗中的应用效果及对脑血流灌注的影响。方法选择2021年5月至2022年5月我院收治的100例急性缺血性脑卒中患者,以随机数字表法将其分为对照组和观察组,各50例。对照组采用常规静脉溶栓治疗,观察组在对照组基础上增加神经节苷脂治疗。比较两组的治疗效果。结果观察组的治疗总有效率为94.00%,显著高于对照组的76.00%,差异具有统计学意义(P<0.05)。治疗前,两组的平均血流量(Qmean)、脑血容量(CBV)、血流峰值时间(TTP)、阻力指数(RI)比较,差异无统计学意义(P>0.05);治疗后,观察组的Qmean、CBV高于对照组,TTP、RI低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的脑源性神经营养因子(BDNF)、神经生长因子(NGF)、γ-氨基丁酸(GABA)水平及美国国立卫生研究院卒中量表(NIHSS)评分比较,差异无统计学意义(P>0.05);治疗后,观察组的BDNF、NGF、GABA水平高于对照组,NIHSS评分低于对照组,差异具有统计学意义(P<0.05)。结论神经节苷脂在急性缺血性脑卒中静脉溶栓治疗中的应用效果显著,可提升临床治疗效果,纠正脑血流灌注状态,促进神经功能修复,值得推广。Objective To investigate the application effect of ganglioside in intravenous thrombolytic therapy for acute ischemic stroke and its influence on cerebral blood perfusion.Methods A total of 100 patients with acute ischemic stroke admitted in our hospital from May 2021 to May 2022 were selected and divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with conventional intravenous thrombolysis,and the observation group was treated with ganglioside on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 94.00%,which was significantly higher than 76.00%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in mean blood flow(Qmean),cerebral blood volume(CBV),time to peak(TTP)and resistance index(RI)between the two groups(P>0.05);after treatment,the Qmean and CBV in the observation group were higher than those in the control group,the TTP and RI were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),γ-aminobutyric acid(GABA)and National Institute of Health Stroke Scale(NIHSS)score between the two groups(P>0.05);after treatment,the levels of BDNF,NGF and GABA in the observation group were higher than those in the control group,the NIHSS score was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusion The ganglioside applied in intravenous thrombolysis for acute ischemic stroke has a significant application effect,which can improve the clinical treatment effect,correct the state of cerebral blood perfusion,and promote the repair of neurological function.It is worth promoting.

关 键 词：神经节苷脂 急性缺血性脑卒中 静脉溶栓 脑血流灌注 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]