miR-10b、miR-466在乳腺癌组织中的表达水平及其与病理参数的相关性分析  

Analysis of expression levels of miR-10b and miR-466 in breast cancer tissues and their correlation with pathological parameters

作　　者：吴媛媛 WU Yuanyuan(Shangluo Central Hospital,Shangluo 726000,China)

机构地区：[1]商洛市中心医院,陕西商洛726000

出　　处：《临床医学研究与实践》2025年第10期94-97,共4页Clinical Research and Practice

摘　　要：目的分析miR-10b、miR-466在乳腺癌组织中的表达水平及其与病理参数的相关性。方法选取2021年6月至2023年6月我院收治的100例乳腺癌患者作为观察组,同期选取乳腺良性肿瘤患者100例作为对照组。检测所有研究对象的miR-10b、miR-466表达水平,比较两组的miR-10b、miR-466表达水平及不同病理参数乳腺癌患者的miR-10b、miR-466表达水平,分析病理参数与乳腺癌患者miR-10b、miR-466表达水平的相关性。结果观察组的miR-10b、miR-466表达水平高于对照组,差异具有统计学意义(P<0.05)。不同年龄、雌激素受体情况乳腺癌患者的miR-10b、miR-466表达水平比较,差异无统计学意义(P>0.05);不同临床分期、肿瘤大小、组织学类型、分化程度、淋巴结转移情况乳腺癌患者的miR-10b、miR-466表达水平比较,差异具有统计学意义(P<0.05)。miR-10b、miR-466表达水平与临床分期、肿瘤大小、组织学类型、分化程度、淋巴结转移情况有关(P<0.05)。结论乳腺癌组织中miR-10b、miR-466表达水平会明显升高,其表达水平与病理参数密切相关,miR-10b、miR-466在乳腺癌的诊断评估中有一定价值,值得临床应用。Objective To analyze the expression levels of miR-10b and miR-466 in breast cancer tissues and their correlation with pathological parameters.Methods A total of 100 patients with breast cancer admitted in our hospital from June 2021 to June 2023 were selected as the observation group,and 100 patients with benign breast tumors were selected as the control group.The expression levels of miR-10b and miR-466 in all subjects were detected,the expression levels of miR-10b and miR-466 in the two groups and the expression levels of miR-10b and miR-466 in breast cancer patients with different pathological parameters were compared,the correlation between pathological parameters and the expression levels of miR-10b and miR-466 in breast cancer patients was analyzed.Results The expression levels of miR-10b and miR-466 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the expression levels of miR-10b and miR-466 in breast cancer patients with different ages and estrogen receptors(P>0.05);the expression levels of miR-10b and miR-466 in breast cancer patients with different clinical stages,tumor size,histological type,differentiation degree and lymph node metastasis were statistically significant(P<0.05).The expression levels of miR-10b and miR-466 were related to clinical stages,tumor size,histological type,differentiation degree and lymph node metastasis(P<0.05).Conclusion The expression levels of miR-10b and miR-466 in breast cancer tissues are significantly increased,and their expression levels are closely related to pathological parameters,miR-10b and miR-466 have certain value in the diagnosis and evaluation of breast cancer,which is worthy of application.

关 键 词：MIR-10B miR-466 乳腺癌 病理参数 

分 类 号：R737.9[医药卫生—肿瘤]