认知障碍的蛋白组学研究进展  

Advances in proteomic research on cognitive disorder

作　　者：裴江燕(综述) 吉维忠(审校)[2] PEI Jiangyan;JI Weizhong(Graduate School of Qinghai University,Xining 810001,China)

机构地区：[1]青海大学研究生院,青海西宁810016 [2]青海省人民医院,青海西宁810007

出　　处：《中风与神经疾病杂志》2025年第3期267-272,共6页Journal of Apoplexy and Nervous Diseases

基　　金：科技成果转化专项项目(2023-SF-107);2022年青海省昆仑英才·高端创新创业人才项目(QHKLYC-GDCXCY-2022-193)。

摘　　要：认知是大脑智能加工过程,影响机体对知识的获取与认识,包括学习、记忆、思维、语言、情感及精神等多方面心理与社会活动。认知障碍则指的是大脑在学习、记忆及思维判断等高级智能活动处理中出现异常,进而导致严重的学习与记忆困难,并伴随失语、失用等病理发展,主要由阿尔茨海默病、脑血管病、头部外伤等疾病引起,目前对于认知障碍的病因研究尚未十分明了。如今,随着现代科技水平的不断发展,蛋白质组学技术在临床医学研究领域得到广泛应用,能为疾病的诊疗及新药的开发提供科学依据。本文就蛋白质组学技术、认知障碍的体液蛋白组学、脑组织蛋白组学以及高原认知障碍的蛋白组学研究进展进行综述,进一步揭示蛋白组学在认知障碍中的应用及发展。Cognition is the intelligent processing of the brain,which affects the acquisition and realization of knowledge in the body,including learning,memory,thinking,language,emotion,spirit,and other psychological and social activities.Cognitive impairment refers to abnormalities in the processing of higher-order intellectual activities in the brain,such as learning,memory,thinking,and judgment,which leads to severe learning and memory difficulties,and it is often accompanied by pathological developments including aphasia and apraxia,which is mainly caused by Alzheimer disease,cerebrovascular diseases,and traumatic brain injury.At present,the etiology of cognitive impairment remains unclear.Nowadays,with the continuous development of modern science and technology,proteomics technology has been widely used in the field of clinical medical research and can provide a scientific basis for the diagnosis and treatment of diseases and the development of new drugs.This article reviews the research advances in proteomics technologies,humoral proteomics of cognitive disorders,brain tissue proteomics,and proteomics research in cognitive disorders at high altitude,in order to further reveal the application and development of proteomics in cognitive disorders.

关 键 词：认知障碍 蛋白组学技术 生物学标志物 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]