帕罗西汀联合喹硫平对双相情感障碍患者认知功能及血清NT-3、5-HT水平的影响  

Effects of Paroxetine Combined with Quetiapine on Cognitive Function and Serum NT-3 and 5-HT Levels in Patients with Bipolar Disorder

作　　者：陆鑫 苏璐 庄倩倩 任蒙蒙 路彩霞 LU Xin;SU Lu;ZHUANG Qianqian;REN Mengmeng;LU Caixia(Department of Neurology,Liaocheng Fourth People's Hospital,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市第四人民医院精神科,山东聊城252000

出　　处：《中外医疗》2025年第8期14-18,共5页China & Foreign Medical Treatment

摘　　要：目的探讨帕罗西汀联合喹硫平治疗双相情感障碍时,对患者血清神经营养因子-3(neurotrophin-3,NT-3)、5-羟色胺(5-hydroxytryptamine,5-HT)及认知功能的影响。方法随机选取2020年3月—2023年3月聊城市第四人民医院收治的110例双相情感障碍患者作为研究对象,以不同治疗方案作为分组标准将患者分为两组,各55例。对照组实施帕罗西汀治疗,观察组实施帕罗西汀联合喹硫平治疗。对两组患者的治疗效果、认知功能、躁狂评分、抑郁评分、生活质量、血清指标以及不良反应的发生情况进行比较分析。结果与观察组的96.36%(53/55)相比,对照组的治疗总有效率为81.82%(45/55),更低,差异有统计学意义(χ^(2)=5.986,P=0.014)。治疗后,观察组的躁狂量表评分、汉密尔顿抑郁量表评分低于对照组,简易精神状态检查表评分、生活质量综合评定问卷得分高于对照组,差异均有统计学意义(P均<0.05)。与对照组相比,治疗后观察组的血清指标水平更优,差异均有统计学意义(P均<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论双相情感障碍治疗中采取帕罗西汀联合喹硫平治疗可有效改善躁狂症状,减轻抑郁程度,治疗效果良好,并促进患者认知功能和神经功能改善,提高生活质量,安全可靠。Objective To investigate the effects of paroxetine combined with quetiapine on cognitive function and serum neurotrophin-3(NT-3)and 5-hydroxytryptamine(5-HT)in patients with bipolar disorder.Methods A total of 110 patients with bipolar disorder admitted to Liaocheng Fourth People's Hospital from March 2020 to March 2023 were randomly selected as the research objects.They were divided into two groups because of different treatment,with 55 cases in each group.The control group was treated with paroxetine,and the observation group was treated with paroxetine combined with quetiapine.The treatment effect,mania score,depression score,cognitive function,quality of life,serum index and adverse reactions were compared between the two groups.Results Compared with 96.36%(53/55)in the observation group,the total effective rate of treatment in the control group was 81.82%(45/55),which was lower,and the difference was statistically significant(χ^(2)=5.986,P=0.014).After treatment,the scores of mania scale and Hamilton Depression Scale in the observation group were lower than those in the control group,and the scores of Mini-mental State Examination and Generic Quality of Life Inventory 74 were higher than those in the control group,the differences were statistically significant(all P<0.05).Compared with the control group,the serum index level of the observation group was better after treatment,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Paroxetine combined with quetiapine in the treatment of bipolar disorder can effectively improve the symptoms of mania,reduce the degree of depression,obtain good therapeutic effect,promote the improvement of cognitive function and neurological function,improve the quality of life,and is safe and reliable.

关 键 词：双相情感障碍 帕罗西汀 喹硫平 认知功能 不良反应 生活质量 

分 类 号：R749[医药卫生—神经病学与精神病学]