0.3%玻璃酸钠和0.1%玻璃酸钠对白内障晶状体超声乳化术后干眼症的改善效果  

The Improvement Effect of 0.3%Sodium Hyaluronate and 0.1%Sodium Hyaluronate on Dry Eye after Phacoemulsification of Cataract Lens

作　　者：万丽[1] 隋文婕 WAN Li;SUI Wenjie(Department of Ophthalmology,BenQ Medical Center Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu,210019,China)

机构地区：[1]南京医科大学附属明基医院眼科,江苏南京210019

出　　处：《中外医疗》2025年第8期74-77,共4页China & Foreign Medical Treatment

摘　　要：目的探究白内障晶状体超声乳化术后干眼症患者应用0.3%玻璃酸钠和0.1%玻璃酸钠治疗效果的差异。方法前瞻性随机选取2023年2月—2024年2月南京医科大学附属明基医院收治的90例白内障晶状体超声乳化术后干眼症患者为研究对象,根据治疗方法不同分为观察组(n=45)、对照组(n=45)。对照组给予小牛血去蛋白提取物滴眼液联合0.1%浓度玻璃酸钠治疗,观察组给予小牛血去蛋白提取物滴眼液联合0.3%浓度玻璃酸钠治疗。比较两组患者不同时间的干眼症状评分、泪膜破裂时间及角膜荧光素染色情况。结果治疗前、治疗28 d,两组患者干眼症状评分比较,差异均无统计学意义(P均>0.05);治疗3 d、7 d,观察组干眼症状评分为(4.71±0.68)分、(3.71±0.83)分均低于对照组的(5.23±0.69)分、(4.18±0.69)分,差异均有统计学意义(t=2.989,2.424;P均<0.05)。治疗前、治疗28 d,两组患者泪膜破裂时间比较,差异均无统计学意义(P均>0.05);治疗3 d、7 d,观察组泪膜破裂时间长于对照组,差异均有统计学意义(P均<0.05)。治疗前、治疗28 d两组患者角膜荧光素染色情况比较,差异均无统计学意义(P均>0.05);治疗3 d、7 d,观察组角膜荧光素染色情况评分低于对照组,差异均有统计学意义(P<0.05)。结论对比浓度0.1%玻璃酸钠,浓度0.3%玻璃酸钠对白内障晶状体超声乳化术后干眼症患者的作用更好,患者干眼症状缓解较优,改善角膜荧光素染色情况,延长泪膜破裂时间。Objective Explore the difference in the therapeutic effect of 0.3%sodium hyaluronate and 0.1%sodium hyaluronate in patients with dry eye after phacoemulsification of cataract lens.Methods A total of 90 patients with dry eye after phacoemulsification in BenQ Medical Center Hospital Affiliated to Nanjing Medical University from February 2023 to February 2024 were prospectively and randomly selected as the study objects,and were divided into observation group(n=45)and control group(n=45)according to different treatment methods.The control group was given deproteinized calf blood extract eye drops combined with 0.1%sodium hyaluronate,and the observation group was given deproteinized calf blood extract eye drops combined with 0.3%sodium hyaluronate.Dry eye symptom score,tear film rupture time and corneal fluorescein staining were compared between the two groups.Results There was no significant difference in dry eye symptom score between the two groups before treatment and 28 d after treatment(both P>0.05).After 3 d and 7 d of treatment,dry eye symptom scores in the observation group were(4.71±0.68)points and(3.71±0.83)points,which were lower than those in the control group(5.23±0.69)points and(4.18±0.69)points,and the differences were statistically significant(t=2.989,2.424;both P<0.05).Before treatment and 28 d after treatment,there were no significant differences in tear film rupture time between the two groups(both P>0.05).After 3 d and 7 d of treatment,the level of tear film rupture time in observation group were higher than those in control group,and the differences were statistically significant(both P<0.05).There was no significant difference in corneal fluorescein staining between the two groups before treatment and 28 d after treatment(both P>0.05).After 3 d and 7 d of treatment,the score of corneal fluorescein staining in observation group were lower than those in control group,and the differences were statistically significant(both P<0.05).Conclusion Compared with 0.1%sodium hyaluronate and 0.3%sodium h

关 键 词：玻璃酸钠 不同浓度 白内障 术后干眼症 干眼症状 泪膜破裂时间 角膜荧光素染色情况 

分 类 号：R777.34[医药卫生—眼科]