老年卵巢癌化疗患者外周血T淋巴细胞亚群及生活质量的动态变化  

Dynamic change of T lymphocyte subsets in peripheral blood and quality of life in elderly patients with ovarian cancer during chemotherapy

作　　者：景雅超 王丽 孙丽敏 吕霞明 石克威 Jing Yachao;Wang Li;Sun Limin;Lyu Xiaming;Shi Kewei(Department of Gynaecology of East Campus,Zhangjiakou First Hospital,Zhangjiakou 075000,Hebei Province,China;Department of Gynaecology of West Campus,Zhangjiakou First Hospital,Zhangjiakou 075000,Hebei Province,China;Department of Gynaecology and Obstetrics,First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei Province,China)

机构地区：[1]张家口市第一医院东院妇科,河北张家口075000 [2]张家口市第一医院西院妇科,河北张家口075000 [3]河北北方学院附属第一医院妇产科,河北张家口075000

出　　处：《中华老年多器官疾病杂志》2025年第3期202-206,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：河北省医学科学研究课题计划(20221897)。

摘　　要：目的观察老年卵巢癌患者化疗期间外周血T淋巴细胞亚群及生活质量的动态变化。方法将2018年3月至2023年6月张家口市第一医院收治的150例拟行化疗的老年卵巢癌患者作为研究对象,分别在化疗前(T_(0))、化疗初期(T_(1))、化疗中期(T_(2))、化疗末期(T_(3))、化疗结束后1个月(T_(4))及结束后3个月时(T_(5))对其生活质量[卵巢癌治疗功能评价系统(FACT-O)]及外周血T淋巴细胞亚群(CD3、CD4、CD8、CD4/CD8)进行观察。采用Pearson相关性分析评估患者各时期免疫状态与其生活质量间的相关性。采用SPSS 22.0软件进行数据分析。根据数据类型,组间比较分别采用t检验及χ^(2)检验。结果剔除中途退出化疗者、不愿填写问卷者及随访者,共129例患者完成化疗及研究指标收集。与T_(0)时相比,患者CD3、CD4、CD4/CD8水平明显降低,T_(2)时开始回升,但T_(5)时水平依旧低于T_(0)时水平(P<0.05);与T_(0)时相比,患者CD8水平明显上升,T_(2)时开始下降,至T_(5)时,CD8水平依旧高于T_(0)时水平(P<0.05)。老年卵巢癌化疗患者FACT-O量表中生理状况得分在T_(0)、T_(1)、T_(2)、T_(3)时呈依次下降趋势,T_(4)、T_(5)时间段内逐渐回升,但依旧低于T_(0)时水平(P<0.05);情感状况及功能状况得分在T_(1)时最低,后逐渐回升,在T_(3)时均恢复至T_(0)时水平,且维持至T_(5)时(P<0.05);卵巢癌特异性模块及量表总得分在T_(0)、T_(1)、T_(2)、T_(3)时呈依次下降趋势,在T_(4)时逐渐回升,但T_(5)时水平依旧低于T_(0)时水平(P<0.05)。Pearson相关性分析提示,老年卵巢癌化疗患者T_(1)时CD4/CD8水平与其同时间段内的生理状况(r=0.412)、功能状况(r=0.374)、卵巢癌特异性模块(r=0.386)以及总得分(r=0.345)间呈正相关(均P<0.001),T_(3)时CD4/CD8水平与其同时间段内生活质量中生理状况(r=0.336)、卵巢癌特异性模块(r=0.325)以及总得分(r=0.394)间呈正相关(均P<0.001)。结论老年卵巢癌患者化疗�Objective To dynamically observe T lymphocyte subsets in the peripheral blood and quality of life in elderly patients with ovarian cancer during chemotherapy.Methods A total of 150 elderly patients with ovarian cancer scheduled to receive chemotherapy in the First Hospital of Zhangjiakou were enrolled in the study from March 2018 to June 2023.The quality of life[functional assessment of cancer therapy-ovary cancer(FACT-O)]and T lymphocyte subsets in the peripheral blood(CD3,CD4,CD8,CD4/CD8)were observed before chemotherapy(T_(0)),at the beginning of chemotherapy(T_(1)),in the middle of chemotherapy(T_(2))and at the end of chemotherapy(T_(3)),at 1 month after the chemotherapy(T_(4)),and at 3 months after chemotherapy(T_(5)).Pearson correlation analysis was used to analyze the correlation between immune status and quality of life of patients at each period.SPSS 22.0 was used for statistical analysis.Data comparison between two groups was performed using t test orχ2 test depending on data type.Results Of all patients,129 completed chemotherapy and research index collection after excluding those who withdrew from chemotherapy,unwilling to fill out the questionnaire and lost to follow-up.Statistics found that the levels of CD3,CD4 and CD4/CD8 were significantly reduced compared with those at T_(0),began to rise at T_(2),but the levels at T_(5) were still lower than those at T_(0)(P<0.05).Compared with that at T_(0),the level of CD8 in patients was increased significantly and began to decrease at T_(2),and the CD8 level at T_(5) was still higher than that at T_(0)(P<0.05).FACT-O score for physiological status in elderly patients with ovarian cancer during chemotherapy showed a decreasing trend at T_(0),T_(1),T_(2) and T_(3),and gradually rose at T_(4) and T_(5),but were still lower than that at T_(0)(P<0.05).The scores of emotional status and functional status were the lowest at T_(1),then were gradually enhanced,returned to the T_(0) level at T_(3) and maintained at T_(5)(P<0.05).The ovarian cancer-specific module sc

关 键 词：老年人 卵巢癌 化疗 生活质量 免疫功能 

分 类 号：R737.31[医药卫生—肿瘤] R592[医药卫生—临床医学]