分层蛋白在子宫内膜癌组织中的表达模式及其对肿瘤进展和预后预测的价值  

Expression of stratifin in endometrial carcinoma tissues and its value in predicting tumor progression and prognosis

作　　者：胡玉霞[1] 邓冉冉 张利玲[1] HU Yu-xia;DENG Ran-ran;ZHANG Li-ling(Department of Obstetrics,The First Hospital of Handan,Handan Hebei 056000,China)

机构地区：[1]邯郸市第一医院产科,河北邯郸056000

出　　处：《临床和实验医学杂志》2025年第6期629-632,共4页Journal of Clinical and Experimental Medicine

基　　金：邯郸市科技计划项目(编号:21422083354);河北省科技计划项目(编号:PEL2422-044)。

摘　　要：目的研究分层蛋白在子宫内膜癌(EC)组织中的表达模式及其对肿瘤进展和预后预测的价值。方法回顾性选取2021年1月至2024年1月邯郸市第一医院收治入院的98例EC患者,设为恶性组;同时,选取同一时期入院的62例良性病症接受全子宫切除术患者,设为良性组。通过免疫组织化学法测定两组患者分层蛋白水平,同时分析分层蛋白水平与EC患者病理特征及预后的相关性。比较不同预后EC患者分层蛋白低表达情况、平均无瘤生存期(DFS)、总生存期(OS)。采用单因素分析和Cox比例风险模型对影响EC患者DFS、OS的危险因素进行分析。结果恶性组分层蛋白阳性表达率为92.86%,高于良性组(24.19%),差异有统计学意义(P<0.05)。恶性组98例EC患者中,分层蛋白高表达79例患者,分层蛋白低表达19例。分层蛋白不同表达水平患者的病理特征比较,仅手术病理学分期差异有统计学意义(P<0.05);分层蛋白表达水平与不同腹腔冲洗细胞学、术前糖类抗原125(CA125)水平、盆/腹腔淋巴结、脉管浸润、年龄、组织学分级无关,差异均无统计学意义(P>0.05)。恶性组98例EC患者随访显示15例复发,83例无瘤生存;11例病死,87例生存。复发患者分层蛋白低表达占比为46.67%,显著高于无瘤生存患者(14.46%),差异有统计学意义(P<0.05)。病死患者分层蛋白低表达占比为63.64%,显著高于生存患者(13.79%),差异有统计学意义(P<0.05)。分层蛋白低表达患者手术后平均DFS、OS分别为(9.24±0.97)、(10.38±1.06)个月,均短于分层蛋白高表达患者[(11.18±1.03)、(12.38±1.15)个月],差异均有统计学意义(P<0.05)。单因素分析结果显示,恶性组DFS在手术病理学分期、组织学分级、分层蛋白水平、盆/腹腔淋巴结转移方面比较,差异均有统计学意义(P<0.05);OS在手术病理学分期、组织学分级、分层蛋白表达水平方面比较,差异均有统计学意义(P<0.05)。Cox比例风险模型Objective To investigate the expression of stratifin in endometrial carcinoma(EC)tissues and its value in predicting tumor progression and prognosis.Methods A total of 98 patients with EC admitted to the First Hospital of Handan from January 2021 to January 2024 were retrospectively selected as the malignant group.At the same time,62 patients with benign diseases who underwent total hysterectomy at the same period were selected as the benign group.The stratifin level of the two groups of patients was determined by immunohistochemical method,and the correlation between stratifin level and the pathological characteristics and prognosis of the patients was analyzed.The low expression of stratified protein,average disease-free survival(DFS)and overall survival(OS)were compared among EC patients with different prognosis.The risk factors of DFS and OS in EC patients were analyzed by univariate analysis and Cox proportional hazard model.Results The positive expression rate of lamellar protein in malignant group was 92.86%,which was higher than that in benign group(24.19%),and the difference was statistically significant(P<0.05).Among the 98 EC patients in the malignant group,79 patients had high expression of layered protein and 19 patients had low expression of layered protein.Compared with the pathological features of patients with different layered protein expression,only the difference in surgical pathological stage was statistically significant(P<0.05).The expression of stratified protein was not related to different peritoneal lavage cytology,preoperative carbohydrate antigen 125(CA125)level,pelvic/abdominal lymph nodes,vascular invasion,age and histological grade(P>0.05).The follow-up of 98 EC patients in the malignant group showed 15 cases of recurrence and 83 cases of tumor-free survival;11 patients died and 87 survived.The proportion of low expression of stratified protein in relapsed patients was 46.67%,which was significantly higher than that in tumor-free survival patients(14.46%),and the difference was sta

关 键 词：子宫内膜肿瘤 预后 免疫组织化学 分层蛋白 病理特征 

分 类 号：R737.33[医药卫生—肿瘤]