应用iRoot BP Plus、MTA直接盖髓后牙髓修复反应变化的大鼠实验研究  

Study on the changes in dental pulp repair response in rats after direct pulp capping using iRoot BP Plus and MTA

作　　者：黄彩霞 张然 李娇娇 韦茄彬 黎淑芳[1] HUANG Caixia;ZHANG Ran;LI Jiaojiao;WEI Jiabin;LI Shufang(Youjiang Medical University For Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院,广西百色533000 [2]朝阳市中心医院口腔科,辽宁朝阳122000 [3]右江民族医学院附属医院口腔科,广西百色533000

出　　处：《口腔医学》2025年第3期191-196,共6页Stomatology

基　　金：广西科技计划项目(2020GXNSFAA297058);广西研究生教育创新计划项目(YCSW2024528);百色市科技项目(百科20221424);自治区级大学生创新创业训练项目(202310599013)。

摘　　要：目的探讨iRoot BP Plus、MTA直接盖髓术后牙髓修复反应变化的异同。方法将36只大鼠随机分为3组,即iRoot BP Plus组、MTA组及空白对照组。对每只大鼠上颌左右第一磨牙进行开髓并行直接盖髓术。术后7、14、28 d于每组中随机选择4只大鼠处死、取标本,行苏木精-伊红(hematoxylin-eosin staing,HE)染色,并观察各指标。结果①从牙本质小管形成质量来看,14、28 d时,iRoot BP Plus组与MTA组比较均具有统计学差异(P<0.05),且iRoot BP Plus在修复性牙本质形成质量方面明显优于MTA。②从修复性牙本质新生面积比值来看,术后14 d,iRoot BP Plus组较MTA组高(P<0.05)。结论iRoot BP Plus、MTA直接盖髓术后均可促进修复性牙本质桥的形成,且形成质量较高,远期效果有待进一步研究。Objective To explore the differences and similarities in the changes of pulp repair response after direct pulp capping with iRoot BP Plus and MTA.Methods A total of 36 male SD rats were randomly divided into 3 groups,namely iRoot BP Plus group,MTA group and blank control group.Dental pulp exposure and direct pulp capping was performed on both sides of maxillary first molars of each rat.Four rats were randomly selected and sacrificed from each group at 7,14,and 28 days postoperatively,and the specimens were taken for hematoxylin-eosin(HE)staining,and then each index was observed.Results①From the perspective of dentin tubular formation quality,at 14 d and 28 d,there were statistical differences between iRoot BP Plus group and MTA group(P<0.05),and iRoot BP Plus was significantly better than MTA in terms of quality of restorative dentin formation.②At 14 days after operation,iRoot BP Plus had a greater area of neodontinin than that in MTA group(P<0.05).Conclusion Both iRoot BP Plus and MTA can promote the formation of restorative dentin bridges after direct pulp capping,and the formation quality is high.The long-term effects need to be further studied.

关 键 词：iRoot BP Plus MTA 直接盖髓术 牙髓修复性牙本质 

分 类 号：R783.1[医药卫生—口腔医学]