广州市新生儿有机氯农药暴露特征及与激素水平的关联性初探  

A preliminary study on the exposure of organochlorine pesticides in neonates and their association with hormone levels in Guangzhou

作　　者：何婷 蔡凤珊 唐斌 严骁 廖其龙 秦瑞欣 马璐[1] 谢春[1] 郑晶 HE Ting;CAI Feng-shan;TANG Bin;YAN Xiao;LIAO Qi-long;QIN Rui-xing;MA Lu;XIE Chun;ZHENG Jing(The Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,School of Public Health,Guizhou Medical University,Guiyang 561113,China;The Key Laboratory of Environmental Pollution Health Risk Assessment,Ministry of Ecology and Environment of the People,s Republic of China,Research Center of Emerging Contaminants,South China Institute of Environmental Sciences,Ministry of Ecology and Environment,Guangzhou 510655,China;State Key Laboratory of Organic Geochemistry,Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]贵州医科大学公共卫生与健康学院,环境污染与疾病监控教育部重点实验室,贵州贵阳561113 [2]生态环境部华南环境科学研究所新污染物研究中心,生态环境部环境污染健康风险评价重点实验室,广东广州510655 [3]中国科学院广州地球化学研究所,有机地球化学国家重点实验室,广东广州510640 [4]中国科学院大学,北京100049

出　　处：《中国环境科学》2025年第4期2264-2275,共12页China Environmental Science

基　　金：环境污染与疾病监控教育部重点实验室开放项目(GMU-2024-HJZ-05);中央级公益性科研院所基本科研业务专项(PM-zx703-202406-177)。

摘　　要：为探讨孕期有机氯农药(OCPs)暴露对新生儿性激素水平和出生体格的影响,以广州市271对母婴人群为研究对象,在新生儿出生后24h内采集胎粪样品,分析胎粪中10种OCPs和7种性激素含量.采用广义线性模型(GLM)分析OCPs与出生体格评分的关联,并采用中介效应模型评估性激素在OCPs暴露与出生体格评分关联的中介作用.结果显示,新生儿胎粪中主要的OCPs为2,2-双-(对氯苯基)-1,1-二氯乙烯(p,p'-DDE),其浓度范围为nd~0.25nmol/g(中值为0.05nmol/g).胎粪中孕酮(Progesterone,P4)、雄烯二酮(Androstenedione,AED)、睾酮(Testosterone,T)、雌酮(Estrone,E1)、雌二醇(Estradiol,E2)、雌三醇(Estriol,E3)等性激素的中值分别为1.80,0.24,0.13,0.15,0.38和8.24nmol/g.p,p'-DDE暴露水平每增加1nmol/g,胎粪中AED、T和E3分别增加1.82(95%CI:0.34,3.29)、1.31(95%CI:0.03,2.60)和8.68(95%CI:3.99,13.4)nmol/g.对于男性新生儿,p,p'-DDE浓度每增加1nmol/g,E3增加9.12(95%CI:3.11,14.9)nmol/g;女性新生儿Σ_(10)OCPs暴露水平每增加1nmol/g,E2/T值减少11.8(95%CI:-22.8,-0.84)nmol/g.p,p'-DDE暴露可能通过调节E3对男性新生儿的身长评分(BLZ)产生影响,其间接效应为0.73,中介效应百分比为25.3%.Σ_(10)OCPs暴露则可能通过调节E2/T对女性新生儿的头围评分(HCZ)产生影响,间接效应为-0.18,中介效应百分比为19.4%.孕期OCPs暴露可能通过调节新生儿性激素水平影响其出生体格评分变化.To investigate the impact of organochlorine pesticides(OCPs)exposure during pregnancy on neonatal sex hormone levels and birth physique,this study recruited 271 mother-infant pairs from Guangzhou and collected meconium samples within 24hours postpartum.The levels of ten OCPs and seven sex hormones in meconium were analyzed.The generalized linear model(GLM)was employed to explore the association between OCP exposure and birth physique scores.Additionally,the mediation effect model was utilized to assess the mediating role of sex hormones in the relationship between OCP exposure and birth physique scores.The results indicated that the predominant OCPs in neonatal meconium was p,p'-DDE,with concentration range of not detected(nd)to 0.25nmol/g(median 0.05nmol/g).The median levels of progesterone(P4),androstenedione(AED),testosterone(T),estrone(E1),estradiol(E2),and estriol(E3)in meconium were 1.80,0.24,0.13,0.15,0.38,and 8.24nmol/g respectively.For each unit increase in p,p'-DDE exposure level,AED,T,and E3 in meconium increased by 1.82(95%CI:0.34,3.29),1.31(95%CI:0.03,2.60),and 211(95%CI:120,302),respectively.In male newborns,for each unit increase in p,p'-DDE concentration was associated with an increase of 9.12(95%CI:3.11,14.9)in E3leevels.Conversely,in female newborns,for each unit increase inΣ_(10)OCPs concentration resulted in a decrease of 11.8(95%CI:-22.8,-0.84)in the E2/T ratio.Exposure to p,p'-DDE may influence the birth length-Zscore(BLZ)in male neonates through the regulation of E3,with an indirect effect of 0.73 and a mediation effect percentage of 25.3%.Exposure toΣ_(10)OCPs may impact head circumference-Zscore(HCZ)in female neonates via regulating E2/T ratio,with an indirect effect of-0.18 and a mediation effect percentage of 19.4%.Exposure to OCPs during pregnancy may affect the changes in birth physique scores of neonates by regulating their sex hormone levels.

关 键 词：有机氯农药 孕期暴露 胎粪 性激素 出生体格 

分 类 号：X18[环境科学与工程—环境科学]