Recent Advances in Intracortical Neural Interfaces for Freely Moving Animals:Technologies and Applications  

作　　者：Xinxia Cai Zhaojie Xu Jingquan Liu Robert Wang Yirong Wu 

机构地区：[1]State Key Laboratory of Transducer Technology,Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100190,China [2]National Key Laboratory of Microwave Imaging Technology,Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100190,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]National Key Laboratory of Science and Technology on Micro/Nano Fabrication,Department of Micro/Nano Electronics,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Engineering》2025年第1期73-86,共14页工程(英文)

基　　金：sponsored by the National Natural Science Foundation of China(62121003,T2293730,T2293731,61960206012,62333020,and 62171434);the National Key Research and Development Program of China(2022YFC2402501 and 2022YFB3205602);the Major Program of Scientific and Technical Innovation 2030(2021ZD02016030)。

摘　　要：Intracortical neural interfaces directly connect brain neurons with external devices to achieve high temporal resolution and spatially precise sampling of neural activity.When applied to freely moving animals,this technology provides in-depth insight into the underlying neural mechanisms for their movement and cognition in real-world scenarios.However,the application of implanted devices in freely moving animals is limited by restrictions on their behavioral freedom and physiologic impact.In this paper,four technological directions for ideal implantable neural interface devices are analyzed:higher spatial density,improved biocompatibility,enhanced multimodal detection of electrical/neurotransmitter signals,and more effective neural modulation.Finally,we discuss how these technological developments have been applied to freely moving animals to provide better insight into neuroscience and clinical medicine.

关 键 词：Intracortical neural interfaces Freely moving animals Microelectrode array NEUROTRANSMITTER 

分 类 号：R318[医药卫生—生物医学工程]