柴芍葛根汤联合泼尼松治疗小儿面神经炎的疗效及对血清TGF-β1、IL-17的影响  

The therapeutic effect of chaishao gegen decoction combined with prednisone on facial neuritis in children and its influences on serum TGF-β1 and IL-17

作　　者：蒋玲玲 田永攀 刘莉莉 宋川 刘晓玲 龚萍 JIANG Lingling;TIAN Yongpan;LIU Lili;SONG Chuan;LIU Xiaoling;GONG Ping(Pain Rehabilitation Department,Chongqing Dazu District People's Hospital,Chongqing 402360,China;Department of Neurology,Chongqing Dazu District People's Hospital,Chongqing 402360,China)

机构地区：[1]重庆市大足区人民医院疼痛康复科,重庆402360 [2]重庆市大足区人民医院神经内科,重庆402360

出　　处：《安徽医药》2025年第5期1036-1040,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨柴芍葛根汤联合泼尼松治疗小儿面神经炎的疗效及对血清转化生长因子-β1(TGF-β1)和白细胞介素-17(IL-17)的影响。方法选取2021年3月至2022年10月在重庆市大足区人民医院进行治疗的80例小儿面神经炎病儿,按照随机数字表法分为观察组和对照组,每组各40例,对照组采用泼尼松治疗,观察组在对照组的基础上给予柴芍葛根汤联合治疗。比较两组治疗疗效及治疗前后面部残疾指数(FDI)、面部神经功能评分(H-B分级量表)、肌电图指标[面神经复合肌动作电位(CMAP)波幅、瞬目反射R1波潜伏期]、血清TGF-β1和IL-17水平变化。结果经过治疗后,观察组总有效率为95.00%,显著高于对照组的77.50%(P<0.05);两组H-B分级、FDI均得到明显改善,且观察组改善效果较对照组更明显(P<0.05);两组病儿CMAP波幅均明显增大,R1波潜伏期均明显缩短,且观察组各项指标较对照组变化更明显(P<0.05);两组病儿TGF-β1水平均明显升高,IL-17水平明显降低,且观察组各项指标较对照组变化更明显(P<0.05)。结论柴芍葛根汤联合泼尼松治疗小儿面神经炎临床效果明显,可有效改善病儿临床症状并减轻机体炎症反应,促进病儿身体恢复,且安全性良好。Objective To investigate the therapeutic effect of chaishao gegen decoction combined with prednisone on facial neuritis in children and its influences on serum transforming growth factor-β1(TGF-β1)and interleukin-17(IL-17).Methods A total of 80 children with facial neuritis who were treated in Dazu District People's Hospital of Chongqing from March 2021 to October 2022 were selected,and 80 patients were assigned into observation group and control group according to random number table,with 40 patients in each group,the patients in the control group were treated with prednisone,and the patients in the observation group were treated with chaishao gegen decoction on the basis of the control group.The therapeutic effects of the two groups were compared,and the changes of facial disability index(FDI),facial nerve function score(H-B scale),electromyographic indicators[amplitude of facial nerve compound muscle action potential(CMAP),latency of blink reflex R1 wave],serum TGF-β1 and IL-17 levels before and after treatment were compared.Results After treatment,the total clinical effective rate of children in the observation group was obviously higher than that of children in the control group(95.00%vs.77.50%,P<0.05);the H-B grade and FDI of children in both groups were obviously improved,and the improvement effects of children in the observation group were more obvious than that in the control group(P<0.05);the amplitude of CMAP in both groups was obviously increased,the latency of R1 wave was obviously shortened,and the changes of all indexes in the observation group were more obvious than those in the control group(P<0.05);the levels of TGF-β1 in the two groups were significantly increased,and the levels of IL-17 were significantly decreased,and the changes in the observation group were more significant than those in the control group(P<0.05).Conclusion Chaishao gegen decoction combined with prednisone has obvious clinical effect in the treatment of children with facial neuritis,which can effectively improve the cli

关 键 词：面神经麻痹 柴芍葛根汤 泼尼松 血清转化生长因子-Β1 白细胞介素-17 

分 类 号：R745.1[医药卫生—神经病学与精神病学]