喹硫平联合丙戊酸钠缓释片对双相情感障碍患者认知功能改善的影响  

Effect of Quetiapine Combined with Sodium Valproate Sustained-release Tablets on Cognitive Function Improvement in Patients with Bipolar Disorder

作　　者：夏俊凝 陈小东 XIA Junning;CHEN Xiaodong(Department of Psychiatric,Lujiang County Third People's Hospital,Hefei 231500,Anhui,China)

机构地区：[1]庐江县第三人民医院精神科,安徽合肥231500

出　　处：《系统医学》2025年第4期83-86,共4页Systems Medicine

摘　　要：目的分析喹硫平、丙戊酸钠缓释片治疗双相情感障碍患者的疗效。方法非随机选取庐江县第三人民医院于2020年1月—2024年2月收治的160例双相情感障碍患者,按治疗方法不同分为两组,各80例。单一用药组采用丙戊酸钠缓释片治疗,联合用药组联合喹硫平治疗。对比两组认知功能、躁狂发作程度、生活质量评分和社会功能评分。结果干预后联合用药组认知功能评分为(277.51±13.84)分,高于单一用药组的(256.38±10.56)分,差异有统计学意义(t=10.856,P<0.05)。干预后联合用药组躁狂发作程度、社会功能评分均低于单一用药组,生活质量评分高于单一用药组,差异有统计学意义(P均<0.05)。结论丙戊酸钠缓释片单一药物治疗效果具有一定局限性,喹硫平联合丙戊酸钠缓释片对双相情感障碍患者认知功能改善显著,可进一步降低躁狂症状对机体产生的负面影响,促进生活质量、社会功能改善。Objective To analyze the efficacy of quetiapine and sodium valproate sustained-release tablets in patients with bipolar disorder.Methods A total of 160 patients with bipolar disorder admitted to the Third People's Hospital of Lujiang County from January 2020 to February 2024 were non-randomly selected and divided into two groups according to different treatment methods,with 80 cases in each group.The single drug group was treated with sodium valproate sustained-release tablets,and the combined drug group was treated with quetiapine.The cognitive function,manic episode degree,quality of life score and social function score were compared between the two groups.Results After intervention,the cognitive function score of the combined drug group was 277.51±13.8,which was higher than 256.38±10.56 of the single drug group,and the difference was statistically significant(t=10.856,P<0.05).After intervention,the severity of manic episodes and social function scores of the combined drug group were lower than those of the single drug group,and the quality of life score was higher than that of the single drug group,and the differences were statistically significant(all P<0.05).Conclusion The single drug treatment effect of sodium valproate sustained-release tablets has certain limitations.Quetiapine combined with sodium valproate sustained-release tablets can significantly improve the cognitive function of patients with bipolar disorder,further reduce the negative impact of manic symptoms on the body,and promote the improvement of quality of life and social function.

关 键 词：双相情感障碍 喹硫平 丙戊酸钠缓释片 社会功能 恢复 躁狂 

分 类 号：R74[医药卫生—神经病学与精神病学]