胞磷胆碱治疗青光眼视神经萎缩的有效性及对患者眼部血流动力学影响研究  

The Effectiveness of the Cytidine Diphosphate Choline Treatment of Glau⁃coma Visual Atrophy and the Study of the Impact on the Patient's Eye Blood Flow Dynamic

作　　者：庞菲菲 王桂江 吴祥鹏 PANG Feifei;WANG Guijiang;WU Xiangpeng(Department of Ophthalmology,Heze Mudan People′s Hospital,Heze 274000,Shandong,China;Shandong Acad-emy of Chinese Medicine,Jinan 250000,Shandong,China;Department of Qingbai,Heze Eur Ophthalmology Hospi-tal,Heze 274000,Shandong,China)

机构地区：[1]菏泽市牡丹人民医院眼科,山东菏泽274000 [2]山东省中医药研究院,山东济南250000 [3]菏泽爱尔眼科医院青白科,山东菏泽274000

出　　处：《系统医学》2025年第1期29-32,共4页Systems Medicine

基　　金：2021年度山东省人文社会科学课题(2021-ZXJK-26)。

摘　　要：目的探讨胞磷胆碱在青光眼视神经萎缩治疗中的应用效果及其对眼部血流动力学的影响。方法非随机选取2023年1—12月菏泽市牡丹人民医院收治的62例青光眼视神经萎缩患者为研究对象,根据治疗方法不同分为两组,各31例;对照组进行常规治疗,观察组则采取胞磷胆碱治疗,对比两组临床疗效。结果观察组治疗总有效率为93.55%(29/31),高于对照组的74.19%(23/31),差异有统计学意义(χ^(2)=4.292,P<0.05)。观察组眼部血流动力学指标、光敏感度、视野缺损度、最佳矫正视力和总灰度值较对照组优,差异有统计学意义(P均<0.05)。观察组与对照组不良反应发生率比较,差异无统计学意义(P>0.05)。结论胞磷胆碱的应用,对于青光眼视神经萎缩患者各项指标的改善有利,可调节视力水平,且安全性高。Objective To explore the application effect of cytidine diphosphate choline in the treatment of glaucoma optic nerve atrophy and its impact on ocular hemodynamics.Methods A total of sixty-two patients with glaucoma and optic nerve atrophy were non-randomly selected as the research objects admitted to Heze Mudan People′s Hospital from January 2023 to December 2023.They were divided into two groups according to different treatment methods,with thirty-one patients in each group;The control group received routine treatment,while the observation group re⁃ceived treatment with cytidine diphosphate choline.The clinical efficacy of the two groups was compared.Results The total effective rate of the observation group was 93.55%(29/31),which was higher than 74.19%(29/31)of the con⁃trol group,and the difference was statistically significant(χ^(2)=4.292,P<0.05).The performance in various indicators,photosensitivity,visual field defect,best corrected visual acuity,and total grayscale values in the observation group performed better than those in the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). Conclusion The application of cytidine diphosphate choline is beneficial for improving vari⁃ ous indicators in patients with glaucoma and optic nerve atrophy, which can regulating visual acuity levels, and has high safety.

关 键 词：青光眼视神经萎缩 胞磷胆碱 眼部血流动力学 

分 类 号：R77[医药卫生—眼科]