痛泻宁颗粒与疏肝健脾方对腹泻型肠易激综合征的治疗效果  

Therapeutic Effect of Tongxiening Granules and Shugan Jianpi Recipe on Diarrheal Irritable Bowel Syndrome

作　　者：刘秋芹 刘云霞[2] 张广林[2] 房贤村 国龙溪 吴华清[2] LIU Qiuqin;LIU Yunxia;ZHANG Guanglin;FANG Xian Cun;GUO Longxi;WU Huaqing(Department of Geriatric Traditional Chinese Medicine,Shouguang People′s Hospital,Shouguang 262700,Shandong,China;Department of Gastroenterology,Shouguang People′s Hospital,Shouguang 262700,Shandong,China;De-partment of General Surgery,Shouguang People′s Hospital,Shouguang 262700,Shandong,China;Department of Di-gestive Medicine,Shouguang Rice Field Center Health Center,Shouguang 262700,Shandong,China)

机构地区：[1]寿光市人民医院老年病中医科,山东寿光262700 [2]寿光市人民医院消化内科,山东寿光262700 [3]寿光市人民医院普外科,山东寿光262700 [4]寿光市稻田中心卫生院消化科,山东寿光262700

出　　处：《系统医学》2025年第1期181-184,共4页Systems Medicine

摘　　要：目的调查痛泻宁颗粒与疏肝健脾方治疗对腹泻型肠易激综合征的效果。方法选取2023年1月—2024年1月寿光市人民医院80例肝郁脾虚型腹泻型肠易激综合征患者为研究对象,按治疗方式不同分为一般组、调查组,各有40例,一般组行痛泻宁颗粒治疗,调查组行疏肝健脾方治疗,比较两组的临床疗效、证候积分,观察胃肠动力学状态,统计不良反应。结果调查组治疗有效率为97.50%(39/40),高于一般组的82.50%(33/40),差异有统计学意义(χ^(2)=5.000,P<0.05)。治疗前,两组腹泻、腹痛、腹胀的证候积分差异无统计学意义(P均>0.05);治疗后,两组证候积分均下降,且调查组明显低于一般组,差异有统计学意义(P均<0.05)。治疗前,两组D-乳酸、胃动素以及血管活性肽水平差异无统计学意义(P均>0.05);治疗后,两组胃肠动力学指标水平均下降,且调查组低于一般组,差异有统计学意义(P均<0.05)。调查组不良反应发生率为10.00%(4/40),与一般组的7.50%(3/40)比较,差异无统计学意义(χ^(2)=0.157,P>0.05)。结论与痛泻宁颗粒相比,疏肝健脾方的效果更好,能迅速减轻腹泻型肠易激综合征相关症状,纠正胃肠动力学代谢状态,且不良反应少。Objective Investigating the efficacy of Tongxie Ning granules and Shugan Jianpi Recipe in treating diar⁃rhea predominant irritable bowel syndrome.Methods From January 2023 to January 2024,80 patients with diarrhea-predominant irritable bowel syndrome of liver depression and spleen deficiency type in Shouguang People′s Hospital were selected as the research objects.According to different treatment methods,they were divided into general group and investigation group,with 40 cases in each group.The general group was treated with Tongxiening Granules,and the investigation group was treated with Shugan Jianpi Recipe.The clinical efficacy and syndrome scores of the two groups were compared,the gastrointestinal motility status was observed,and the adverse reactions were counted.Re⁃sults The effective rate of treatment in the investigation group was 97.50%(39/40),which was higher than 82.50%(33/40)in the general group,and the difference was statistically significant(χ^(2)=5.000,P<0.05).Before treatment,there was no significant difference in the symptom scores of diarrhea,abdominal pain and abdominal distension between the two groups(all P>0.05).After treatment,the symptom scores of the two groups decreased,and the investigation group was significantly lower than the general group,the difference was statistically significant(all P<0.05).Before treat⁃ment,there was no significant difference in the levels of D-lactic acid,motilin and vasoactive peptide between the two groups(all P>0.05).After treatment,the levels of gastrointestinal motility indexes in the two groups decreased,and those in the investigation group were lower than the general group,the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the investigation group was 10.00%(4/40),compared with 7.50%(3/40)in the general group,the difference was not statistically significant(χ^(2)=0.157,P>0.05).Conclusion Compared with Tongxiening Granules,Shugan Jianpi Recipe has better effect,can quickly reduce the symptoms rela

关 键 词：疏肝健脾方 不良反应 肠易激综合征 临床疗效 腹泻型 痛泻宁颗粒 

分 类 号：R574.4[医药卫生—消化系统]