甲状腺乳头状癌HRAS和TERT启动子突变与超声特征的相关性分析  

Correlation analysis between HRAS and TERT promoter mutations and ultrasound features in papillary thyroid carcinoma

作　　者：徐文文 Xu Wen-wen(Ultrasound Room,Zhengzhou Traditional Chinese Medicine Hospital,Zhengzhou 450007,China)

机构地区：[1]郑州市中医院彩超室,河南郑州450007

出　　处：《四川生理科学杂志》2025年第4期757-759,870,共4页

摘　　要：目的:探讨与分析甲状腺乳头状癌HRAS和TERT启动子突变与超声特征的相关性,以明确甲状腺乳头状癌HRAS和TERT启动子突变的价值与促进推广应用超声诊断。方法:2021年2月到2024年1月选择在本院诊治的甲状腺乳头状癌患者108例作为研究对象,取所有患者的空腹静脉血3mL左右,采用荧光定量PCR扩增检测HRAS和TERT启动子突变情况。所有患者都给予超声检查,记录超声特征并进行相关性分析。结果:在108例患者中,判断为HRAS启动子突变18例,占比16.67%;TERT启动子突变36例,占比33.33%。不同性别、年龄、淋巴结转移、侵犯甲状腺外、侵犯被膜、肿瘤位置患者的HRAS和TERT启动子突变率对比无明显差异(P>0.05)。超声判断显示纵横比≥1有46例,纵横比<1有62例;内部低回声75例,等回声33例;边缘清晰49例,欠清晰59例;钙化70例,无钙化38例。不同内部回声、边缘、钙化患者的HRAS和TERT启动子突变情况对比有统计学意义差异(P<0.05)。Spearsman分析显示HRAS和TERT启动子突变与超声特征(内部回声、边缘、钙化)等存在相关性(P<0.05)。结论:甲状腺乳头状癌HRAS和TERT启动子突变比较常见,其中TERT启动子突变率更高,超声是甲状腺乳头状癌的首选检查方法,甲状腺乳头状癌HRAS和TERT启动子突变与超声特征存在相关性,有助于提供更精准的诊断和治疗指导。Objective:To explore and analyze the correlation between HRAS and TERT promoter mutations and ultrasound features in papillary thyroid carcinoma,in order to clarify the value of HRAS and TERT promoter mutations in papillary thyroid carcinoma and promote the promotion and application of ultrasound diagnosis.Methods:From February 2021 to January 2024,108 patients with papillary thyroid carcinoma treated in our hospital were selected as the research subjects.Fasting venous blood samples of about 3mL were collected from all patients,and fluorescent quantitative PCR amplification was used to detect HRAS and TERT promoter mutations.All patients were given ultrasound examination,ultrasound features were recorded,and correlation analysis was conducted.Results:Among the 108 patients,18 were diagnosed with HRAS promoter mutations,accounting for 16.67%;There were 36 cases of TERT promoter mutations,accounting for 33.33%.There was no significant difference in the mutation rates of HRAS and TERT promoters among patients of different genders,ages,lymph node metastasis,invasion of the thyroid gland,invasion of the capsule,and tumor location(P>0.05).Ultrasound diagnosis showed that there were 146 cases with aspect ratio≥1 and 162 cases with aspect ratio<1;75 cases of internal hypoechogenicity and 33 cases of isoechogenicity;49 cases had clear edges and 59 cases had unclear edges;There were 70 cases of calcification and 38 cases without calcification.There was a statistically significant difference(P<0.05)in the mutation status of HRAS and TERT promoters among patients with different internal echoes,edges,and calcifications.Spearman analysis showed a correlation(P<0.05)between HRAS and TERT promoter mutations and ultrasound features such as internal echoes,edges,and calcification.Conclusion:HRAS and TERT promoter mutations are common in papillary thyroid carcinoma,with a higher rate of TERT promoter mutations.Ultrasound is the preferred diagnostic method for papillary thyroid carcinoma,and there is a correlation between HRAS an

关 键 词：甲状腺乳头状癌 HRAS启动子突变 TERT启动子突变 超声特征 纵横比 

分 类 号：R736.1[医药卫生—肿瘤]