老年食管癌三维适形放疗后左室心肌损伤影响因素分析  

Analysis of influencing factors of left ventricular myocardial injury after three dimensional conformal radiotherapy in elderly patients with esophageal cancer

作　　者：菅志华 Jian Zhi-hua(Department of Radiotherapy,Anyang Regional Hospital,Puyang 455000,Henan,China)

机构地区：[1]濮阳市安阳地区医院放疗科,河南濮阳455000

出　　处：《四川生理科学杂志》2025年第4期838-841,共4页

摘　　要：目的:探究老年食管癌三维适形放疗后左室心肌损伤相关影响因素。方法:回顾性选取2021年12月至2024年6月在本院行食管癌三维适形放疗的老年患者113例作为研究对象。分析放疗后患者的左室心肌损伤状况,并根据左室心肌损伤状况将患者分为无损伤组和损伤组。收集并对比两组的基线资料。采用多因素logistic回归分析老年食管癌三维适形放疗后左室心肌损伤的影响因素。结果:入组113例患者中,治疗后一个月完全缓解76例,部分缓解32例,近期总有效率为95.57%。113例老年食管癌三维适形放疗后,发生左室心肌损伤的患者有37例,发生率为32.74%。单因素分析发现,损伤组高血压史比例、高血脂史比例、放疗高剂量比例、癌胚抗原(Carcinoembryonic antigen,CEA)、鳞状上皮细胞癌抗原(Squamous cell carcinoma antigen,SCC)水平均高于无损伤组(P<0.05)。两组的放射性肺炎、食管炎、胃肠道反应、放射性皮炎等并发症发生率比较差异无统计学意义。经Logistic回归分析结果显示,高血压史、高血脂史、放疗剂量、血清CEA、SCC水平为老年食管癌三维适形放疗后左室心肌损伤的影响因素(P<0.05)。结论:高血压史、高血脂史、放疗剂量、血清CEA、SCC水平为老年食管癌三维适形放疗后左室心肌损伤的影响因素。Objective:To explore the influencing factors of left ventricular myocardial injury after three-dimensional conformal radiotherapy in elderly patients with esophageal cancer.Methods:113 elderly patients received three-dimensional conformal radiotherapy for esophageal cancer in our hospital from December 2021 to June 2024 were retrospectively selected as the study objects.The status of left ventricular myocardial injury after radiotherapy was analyzed,and the patients were divided into two groups according to the status of left ventricular myocardial injury.Baseline data were collected and compared between the two groups.Multivariate logistic regression was used to analyze the influencing factors of left ventricular myocardial injury after three-dimensional conformal radiotherapy in elderly patients with esophageal cancer.Results:Of the 113 patients enrolled,One month after treatment,76 patients were complete remission and 32 patients were partial remission,the overall recent response rate was 95.57%.After three dimensional conformal radiotherapy,37 cases of left ventricular myocardial injury occurred in 113 patients.And the incidence of left ventricular myocardial injury was 32.74%.Univariate analysis showed that in the injury group,the proportion of hypertension,hyperlipidemia,the proportion of high dose of radiotherapy,carcinoembryonic antigen(CEA),and squamous cell carcinoma antigen(SCC)levels were higher than those of the non-injury group(P<0.05).There were no significant differences in the incidence of radiation pneumonia,esophagitis,gastrointestinal reaction and radiation dermatitis between the two groups.Logistic regression analysis showed that history of hypertension,history of hyperlipidemia,radiotherapy dose,serum CEA and SCC levels were the influencing factors of left ventricular myocardial injury after three-dimensional conformal radiotherapy for elderly esophageal cancer(P<0.05).Conclusion:History of hypertension,history of hyperlipidemia,radiotherapy dose,serum CEA and SCC levels are the influential

关 键 词：老年食管癌 三维适形放疗 左室心肌损伤 影响因素 

分 类 号：R735.1[医药卫生—肿瘤]