艾司西酞普兰联合米氮平对老年脑卒中合并抑郁患者认知功能的影响分析  

Analysis of the Effect of Escitalopram Combined with Mirtazapine on Cognitive Function in Elderly Stroke Patients with Depression

作　　者：徐岳 常佳 XU Yue;CHANG Jia(Admission Center Ward,Baoji Rehabilitation Hospital,Baoji 721000,Shaanxi,China)

机构地区：[1]宝鸡市康复医院收治中心病区,陕西宝鸡721000

出　　处：《系统医学》2025年第5期93-96,共4页Systems Medicine

摘　　要：目的调查老年脑卒中并抑郁患者实施艾司西酞普兰+米氮平治疗的效果。方法非随机选取2022年12月—2024年3月宝鸡市康复医院收治中心收治的50例老年脑卒中合并抑郁的患者为研究对象,根据治疗方式不同分为单独组、联合组,各25例。所有患者均给予常规脑卒中治疗,在此基础上,单独组给予艾司西酞普兰治疗,联合组加用米氮平治疗。比较两组临床疗效、认知情况、神经代谢指标、不良反应。结果联合组治疗有效率为96.00%(24/25),高于单独组的68.00%(17/25),差异有统计学意义(χ^(2)=4.878,P<0.05)。联合组治疗后的认知功能评分高于单独组,差异有统计学意义(P<0.05)。联合组治疗后的5-羟色胺和25-羟基维生素D3均高于单独组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论艾司西酞普兰+米氮平结合后能提升认知功能,纠正神经递质代谢情况,降低抑郁水平,并具有一定的安全性。Objective To investigate the effect of escitalopram+mirtazapine in elderly patients with stroke and depression.Methods From December 2022 to March 2024,fifty elderly patients with stroke and depression admitted to Admission Center Ward of Baoji Rehabilitation Hospital were non-randomly selected as the research objects.According to different treatment methods,they were divided into single group and combined group,with twenty-five cases in each group.All patients were given conventional stroke treatment.On this basis,the single group was treated with escitalopram,and the combined group was treated with mirtazapine.The clinical efficacy,cognitive status,nerve metabolism indexes and adverse reactions were compared between the two groups.Results The effective rate of treatment in the combined group was 96.00%(24/25),which was higher than 68.00%(17/25)in the single group,and the difference was statistically significant(χ^(2)=4.878,P<0.05).The cognitive function score of the combined group after treatment was higher than that of the single group,and the difference was statistically significant(P<0.05).After treatment,the levels of 5-hydroxytryptamine and 25-hydroxyvitamin D3 in the combined group were higher than those in the single group,and the differences were statistically significant(both P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of escitalopram and mirtazapine can improve cognitive function,correct neurotransmitter metabolism,reduce depression level,and has certain safety.

关 键 词：老年脑卒中 米氮平 临床疗效 抑郁 神经代谢 艾司西酞普兰 

分 类 号：R743.3[医药卫生—神经病学与精神病学]