老年结直肠癌手术患者血清hs-CRP、IL-10水平与预后的关系研究  

Relationship Between Serum hs-CRP and IL-10 Levels and Prognosis in Elderly Patients Undergoing Operation for Colorectal Cancer

作　　者：王飞 WANG Fei(Department of Gastrointestinal Surgery,Wuxi Second Geriatric Hospital,Wuxi 214174,Jiangsu,China)

机构地区：[1]无锡市第二老年病医院胃肠外科,江苏无锡214174

出　　处：《系统医学》2025年第5期146-149,共4页Systems Medicine

摘　　要：目的探究老年结直肠癌手术患者的血清超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)和白细胞介素10(interleukin 10,IL-10)水平与手术预后的关系。方法回顾性选取2020年1月—2023年12月无锡市第二老年病医院80例行手术治疗的老年结直肠癌患者的临床资料,根据预后分成两组,预后良好为对照组(n=44),预后不良为观察组(n=36)。比较两组的临床资料和hs-CRP、IL-10水平,使用Logistic回归分析法对老年结直肠癌手术预后的影响因素进行分析,应用ROC曲线分析上述指标对预后的预测效能。结果术后接受化疗为患者预后的独立保护因素,中高分化程度、疾病分期(Ⅱ、Ⅲ期)、肿瘤直径>5.49 cm、hs-CRP>30.82 mg/L、IL-10>25.33 pg/mL为预后不良的独立危险因素(OR=0.530、2.121、2.164、2.218、4.614、4.214,P均<0.05)。hs-CRP预测老年结直肠癌手术预后AUC为0.759,敏感度为0.845、特异度为0.897;IL-10预测老年结直肠癌手术预后AUC为0.741,敏感度为0.826、特异度为0.858。结论血清hs-CRP、IL-10水平升高会增加老年结直肠癌手术患者预后不良风险,在一定程度上可预测患者预后。Objective To explore the relationship between serum high sensitivity C-reactive protein(hs-CRP)and interleukin 10(IL-10)levels and postoperative prognosis in elderly patients undergoing colorectal cancer surgery.Methods The clinical data of eighty elderly patients with colorectal cancer who underwent surgical treatment in Wuxi Second Geriatric Hospital from January 2020 to December 2023 were retrospectively selected and divided into two groups according to prognosis:control group with good prognosis(n=44)and observation group with poor prognosis(n=36).The clinical data and the levels of hs-CRP and IL-10 of the two groups were compared.Logistic regression analysis was used to analyze the influencing factors of postoperative prognosis of elderly colorectal cancer,and ROC curve was used to analyze the predictive efficacy of the above indicators on prognosis.Results Postoperative chemotherapy was an independent protective factor for prognosis,middle-high differentiation degree,disease stage(Ⅱ,Ⅲ),tumor diameter>5.49 cm,hs-CRP>30.82 mg/L,IL-10>25.33 pg/mL were independent risk factors for poor prognosis(OR=0.530,2.121,2.164,2.218,4.614,4.214,all P<0.05).hs-CRP predicted the postoperative prognosis of elderly colorectal cancer with AUC 0.759,sensitivity 0.845 and specificity 0.897.The AUC,sensitivity and specificity of IL-10 for predicting postoperative prognosis of elderly colorectal cancer were 0.741,0.826 and 0.858 respectively.Conclusion The increase of serum hs-CRP and IL-10 levels can increase the risk of poor prognosis in elderly patients with colorectal cancer surgery,which can predict the prognosis of patients to a certain extent.

关 键 词：血清超敏C反应蛋白 血清白细胞介素10 结直肠癌 预后效果 

分 类 号：R735[医药卫生—肿瘤]