乳腺浸润性小叶癌的分子特征与预后标志物研究  

Study on molecular characteristics and prognostic markers of invasive lobular carcinoma of the breast

作　　者：刘柔嘉 LIU Rou-jia(Putian University Affiliated Hospital,Putian 351100,China)

机构地区：[1]莆田学院附属医院,351100

出　　处：《中国现代药物应用》2025年第6期34-36,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探究乳腺浸润性小叶癌(ILC)患者的分子特征和预后标志物,为临床干预乳腺浸润性小叶癌患者治疗提供基础。方法选取62例乳腺浸润性小叶癌患者纳入试验组,另选取同期62例乳腺浸润性导管癌患者纳入对照组。比较两组患者基本资料(年龄、绝经状态、超声分级、钼乳腺核磁分级);E-钙黏附蛋白(E-cadherin)表达缺失率和p120-连环素蛋白(p120-catenin)表达率;免疫组化相关因子[Ki-67、人类表皮生长因子受体2(HER2)、雌激素受体(ER)、孕激素受体(PR)]阳性表达率;2年总生存率。结果两组患者年龄、绝经状态、超声分级、钼乳腺核磁分级比较,无统计学差异(P>0.05)。试验组患者的E-cadherin表达缺失率54.84%(34/62)、p120-catenin表达率66.13%(41/62)高于对照组的19.35%(12/62)、20.97%(13/62)(P<0.05)。试验组患者ER、PR、HER2、Ki-67的阳性表达率分别为72.58%、74.19%、77.42%、70.97%,均高于对照组的38.71%、33.87%、37.10%、37.10%(P<0.05)。试验组患者2年总生存率为80.65%(50/62),高于对照组的59.68%(37/62)(P<0.05)。结论乳腺浸润性小叶癌是乳腺癌疾病中一种浸润性较强的类型,了解乳腺浸润性小叶癌患者的分子特征,有助于临床鉴别乳腺浸润性小叶癌和乳腺浸润性导管癌两种疾病,同时能够实现对患者预后的评估。Objective To explore the molecular characteristics and prognostic markers of invasive lobular carcinoma(ILC)of the breast,and provide a basis for clinical intervention in the treatment of patients with invasive lobular carcinoma of the breast.Methods 62 patients with invasive lobular carcinoma of the breast were included in the experimental group;another 62 patients with invasive ductal carcinoma of the breast during the same period were included in the control group.Comparison of basic adta(age,menopausal status,ultrasound grading,molybdenum mammary nuclear magnetic grading),loss rate of E-cadherin expression and p120-catenin expression rate,positive expression rates of immunohistochemical related factors[Ki-67,human epidermal growth factor receptor 2(HER2),estrogen receptor(ER),progesterone receptor(PR)],and 2-year overall survival rate between the two groups.Results There were no significant differences in age,menopausal status,ultrasound grading,molybdenum mammary nuclear magnetic grading between the two groups(P>0.05).The loss rate of E-cadherin expression and p120-catenin expression rate in the experimental group were 54.84%(34/62)and 66.13%(41/62),which were higher than 19.35%(12/62)and 20.97%(13/62)in the control group(P<0.05).The positive expression rates of ER,PR,HER2 and Ki-67 in the experimental group were 72.58%,74.19%,77.42%and 70.97%,which were higher than 38.71%,33.87%,37.10%and 37.10%in the control group(P<0.05).The 2-year overall survival rate of the experimental group was 80.65%(50/62),which was higher than 59.68%(37/62)of the control group(P<0.05).Conclusion Invasive lobular carcinoma of the breast is a highly invasive type of breast cancer.Understanding the molecular characteristics of patients with invasive lobular carcinoma of the breast can help to clinically differentiate invasive lobular carcinoma of the breast from invasive ductal carcinoma of the breast,and at the same time can achieve the assessment of the patient's prognosis.

关 键 词：乳腺浸润性小叶癌 分子特征 预后标志物 临床研究 

分 类 号：R737.9[医药卫生—肿瘤]