调强适形放疗联合化疗治疗老年晚期宫颈癌患者的效果、安全性及对生活质量的影响评价  

Evaluation of effect,safety of intensity-modulated radiotherapy combined with chemotherapy in elderly patients with advanced cervical cancer and its influence on quality of life of patients S

作　　者：孙亚男 UN Ya-nan(Department of Gynecology,Weihai Maternal and Child Health Hospital,Weihai 264200,China)

机构地区：[1]威海市妇幼保健院妇科,264200

出　　处：《中国现代药物应用》2025年第6期90-93,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析调强适形放疗与化疗联合治疗老年晚期宫颈癌患者的效果、安全性及对生活质量的影响。方法78例老年晚期宫颈癌患者,随机分为研究组与对照组,各39例。对照组以化疗方式治疗,研究组以调强适形放疗与化疗联合治疗。比较两组治疗前后肿瘤标志物[鳞状细胞癌相关抗原(SCCAg)、糖类抗原50(CA-50)、癌胚抗原(CEA)]、免疫功能[免疫球蛋白M(IgM)和免疫球蛋白A(IgA)]及治疗后生活质量、不良反应发生情况。结果两组治疗后的SCCAg、CA-50、CEA水平均显著低于治疗前,且研究组SCCAg(1.22±0.34)μg/L、CA-50(18.11±2.45)U/ml、CEA(1.73±0.67)μg/L显著低于对照组的(3.12±0.45)μg/L、(30.52±2.78)U/ml、(3.56±0.89)μg/L(P<0.05)。两组治疗后的IgA、IgM水平均比治疗前有所降低,但研究组IgA(2.22±0.24)g/L、IgM(1.31±0.25)g/L均显著高于对照组的(1.92±0.25)、(1.05±0.18)g/L(P<0.05)。研究组社会功能、活力、情绪状态评分分别为(84.80±5.03)、(69.05±4.53)、(85.25±6.12)分,显著高于对照组的(73.52±5.09)、(57.72±4.71)、(74.68±6.26)分(P<0.05)。研究组的不良反应发生率12.82%与对照组的10.26%比较无统计学差异(P>0.05)。结论老年晚期宫颈癌患者使用调强适形放疗与化疗联合治疗具有效果好、安全性高的特点,且有助于提高患者的生活质量。Objective To analyze the effect,safety of intensity-modulated radiotherapy combined with chemotherapy in elderly patients with advanced cervical cancer and its influence on quality of life of patients.Methods 78 elderly patients with advanced cervical cancer were randomly divided into study group and control group,each with 39 cases.The control group was treated with chemotherapy,and the study group was treated with intensity-modulated radiotherapy combined with chemotherapy.Both groups were compared in terms of tumor markers[squamous cell carcinoma antigen(SCCAg),carbohydrate antigen 50(CA-50),carcinoembryonic antigen(CEA)],immune function[immunoglobulin M(IgM)and immunoglobulin A(IgA)],quality of life and occurrence of adverse reactions after treatment.Results After treatment,the levels of SCCAg,CA-50 and CEA in both groups were significantly lower than those before treatment;the study group had SCCAg of(1.22±0.34)μg/L,CA-50 of(18.11±2.45)U/ml,and CEA of(1.73±0.67)μg/L,which were significantly lower than(3.12±0.45)μg/L,(30.52±2.78)U/ml,and(3.56±0.89)μg/L in the control group(P<0.05).After treatment,the levels of IgA and IgM in both groups were lower than those before treatment;the study group had IgA of(2.22±0.24)g/L and IgM of(1.31±0.25)g/L,which were significantly higher than(1.92±0.25)and(1.05±0.18)g/L in the control group(P<0.05).The scores of social function,vitality and emotional state of the study group were(84.80±5.03),(69.05±4.53)and(85.25±6.12)points,which were significantly higher than(73.52±5.09),(57.72±4.71)and(74.68±6.26)points of the control group(P<0.05).The incidence of adverse reactions in the study group was 12.82%,which had no statistical significance compared with 10.26%in the control group(P>0.05).Conclusion The combination therapy of intensity-modulated radiotherapy and chemotherapy for elderly patients with advanced cervical cancer has the characteristics of good efficacy and high safety,and can help improve the quality of life of patients.

关 键 词：晚期宫颈癌 化疗 调强适形放疗 生活质量 安全性 老年 

分 类 号：R737.33[医药卫生—肿瘤]