胃癌根治术后肠内营养与肠外营养的应用效果对比  

Comparison of application effect of enteral nutrition and parenteral nutrition after radical gastrectomy for gastric cancer

作　　者：蔡静娴 张玮 CAI Jing-xian;ZHANG Wei(Department of Pharmacy,Xinrui Hospital of Xinwu District(Ruijin Hospital Wuxi Branch Hospital Affiliated to Medical College of Shanghai Jiao Tong University),Wuxi 214142,China)

机构地区：[1]无锡市新吴区新瑞医院(上海交通大学医学院附属瑞金医院无锡分院)药学部,214142

出　　处：《中国现代药物应用》2025年第6期157-160,共4页Chinese Journal of Modern Drug Application

摘　　要：目的对比胃癌根治术后患者实施肠内营养与肠外营养的效果。方法在实施胃癌根治术治疗的胃癌患者中随机选取接受术后肠外营养支持的50例胃癌患者与接受术后肠内营养支持的50例胃癌患者作为研究对象,分别设为对照组与研究组。对比两组营养指标、体重减轻量、血清炎性因子指标、术后并发症发生率、术后恢复时间。结果两组患者的血红蛋白、白蛋白、前白蛋白在干预后均较干预前增高,且研究组患者干预后的血红蛋白(125.94±6.87)g/L、白蛋白(41.15±2.54)g/L、前白蛋白(305.62±36.48)mg/L均较同期对照组的(117.52±6.39)g/L、(38.27±2.31)g/L、(264.59±32.67)mg/L更高(P<0.05)。研究组术后第7天较术后第1天的体重减轻量(2.55±0.52)kg小于对照组的(4.49±0.67)kg(P<0.05)。干预后,两组血清C反应蛋白、降钙素原均比干预前低,且研究组的血清C反应蛋白(5.68±1.06)mg/L、降钙素原(0.46±0.14)ng/ml均比对照组的(6.92±1.17)mg/L、(0.69±0.21)ng/ml低(P<0.05)。研究组术后并发症发生率略低于对照组,但差异无统计学意义(P>0.05)。研究组术后首次排气时间、首次排便时间、首次下床活动时间及术后住院天数分别为(0.91±0.29)、(1.40±0.48)、(1.63±0.36)、(12.54±1.98)d,均比对照组的(1.30±0.34)、(1.89±0.52)、(2.07±0.41)、(14.89±2.10)d短(P<0.05)。结论在胃癌根治术后采取肠内营养支持较肠外营养更能改善胃癌患者的营养状况,减少体重损失,肠内营养还可促进患者术后胃肠功能恢复,减少术后并发症,加快术后康复速度,缩短术后住院时间。Objective To compare the effect of enteral nutrition and parenteral nutrition after radical gastrectomy for gastric cancer.Methods 50 gastric cancer patients who received postoperative parenteral nutrition support and 50 gastric cancer patients who received postoperative enteral nutrition support were randomly selected as the study subjects,and were set as the control group and the study group,respectively.The nutritional indicators,weight loss,serum inflammatory factor indicators,incidence of postoperative complications and postoperative recovery time were compared between the two groups.Results After intervention,the hemoglobin,albumin and prealbumin in both groups were increased compared with before intervention;the study group had hemoglobin of(125.94±6.87)g/L,albumin of(41.15±2.54)g/L,and prealbumin of(305.62±36.48)mg/L,which were higher than(117.52±6.39)g/L,(38.27±2.31)g/L,and(264.59±32.67)mg/L in the control group(P<0.05).The weight loss of the study group was(2.55±0.52)kg on the 7th day after surgery compared to the 1st day after surgery,which was less than(4.49±0.67)kg of the control group(P<0.05).After intervention,the serum C-reactive protein and procalcitonin in both groups were lower than those before intervention;the study group had serum C-reactive protein of(5.68±1.06)mg/L and procalcitonin of(0.46±0.14)ng/ml,which were lower than(6.92±1.17)mg/L and(0.69±0.21)ng/ml in the control group(P<0.05).The incidence of postoperative complications in the study group was slightly lower than that in the control group,but the difference was not statistically significant(P>0.05).In the study group,the first postoperative exhaust time,first defecation time,first ambulation time and postoperative hospitalization days were(0.91±0.29),(1.40±0.48),(1.63±0.36)and(12.54±1.98)d,which were shorter than(1.30±0.34),(1.89±0.52),(2.07±0.41)and(14.89±2.10)d in the control group(P<0.05).Conclusion Enteral nutrition support is more effective than parenteral nutrition in improving the nutritional status of g

关 键 词：胃癌 胃癌根治术 肠内营养 肠外营养 

分 类 号：R735.2[医药卫生—肿瘤]