清肝利胆汤加减治疗对肝胆湿热型慢性胆囊炎患者中医证候积分及炎症因子的影响  

Effect of Modified Qinggan Lidan Decoction on Traditional Chinese Medicine Syndrome Scores and Inflammatory Factors in Patients with Chronic Cholecystitis of Liver and Gallbladder Damp Heat Type

作　　者：段晓东 DUAN Xiaodong(Department of Spleen,Stomach,Liver and Gallbladder,Jinan Hospital of Guang’anmen Hospital of China Academy of Chinese Medical Sciences(Jinan Traditional Chinese Medicine Hospital),Jinan 250000,China)

机构地区：[1]中国中医科学院广安门医院济南医院(济南市中医医院)脾胃肝胆科,山东济南250000

出　　处：《反射疗法与康复医学》2025年第6期1-4,20,共5页Reflexology And Rehabilitation Medicine

基　　金：济南市卫生健康委员会科技发展计划项目(项目编号:2022-中-02)。

摘　　要：目的分析清肝利胆汤加减治疗对肝胆湿热型慢性胆囊炎患者的影响。方法选取2022年7月-2024年7月中国中医科学院广安门医院济南医院(济南市中医医院)收治的84例肝胆湿热型慢性胆囊炎患者为研究对象,按随机数字表法将其分为对照组和观察组,各42例。对照组采用常规西医治疗,观察组在对照组基础上采用清肝利胆汤加减治疗。对比两组的临床疗效、中医证候积分、胆囊功能、炎症因子、不良反应发生情况。结果观察组治疗总有效率为95.24%,高于对照组的的78.57%,差异有统计学意义(P<0.05)。治疗4周后,两组各项中医证候积分均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05);两组胆囊壁厚度均薄于治疗前,且观察组薄于对照组,两组空腹胆囊容积均小于治疗前,且观察组小于对照组,两组胆囊收缩率均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组C反应蛋白、白细胞介素-6、肿瘤坏死因子-α水平均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。两组均无不良反应发生。结论清肝利胆汤加减治疗肝胆湿热型慢性胆囊炎患者能缓解相关症状,降低炎症因子水平,改善胆囊功能,且安全可行。Objective Analysis of the effect of modified Qinggan Lidan Decoction on patients with chronic cholecystitis of liver and gallbladder damp heat type.Methods A total of 84 patients with chronic cholecystitis of liver and gallbladder damp heat type admitted to Jinan Hospital of Guang'anmen Hospital of China Academy of Chinese Medical Sciences(Jinan Traditional Chinese Medicine Hospital)from July 2022 to July 2024 were selected as the research subjects,according to the random number table method,they were divided into a control group and an observation group,with 42 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with modified Qinggan Lidan Decoction on the basis of the control group.Compare the clinical efficacy,traditional Chinese medicine syndrome score,gallbladder function,inflammatory factors,and occurrence of adverse reactions between the two groups.Results The total effective rate of the observation group was 95.24%,which was higher than the 78.57%of the control group,the difference was statistically significant(P<0.05).After 4 weeks of treatment,the scores of various traditional Chinese medicine syndromes in both groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05);the thickness of the gallbladder wall in both groups were thinner than those before treatment,and the observation group was thinner than that in the control group,the fasting gallbladder volume in both groups were smaller than those before treatment,and the observation group was smaller than that in the control group,the gallbladder contraction rate in both groups were higher than those before treatment,and the observation group was higher than that in the control group,the differences were statistically significant(P<0.05);the levels of C-reactive protein,interleukin-6,and tumor necrosis factor alpha in both groups were lower than those before treatment,and

关 键 词：慢性胆囊炎 肝胆湿热型 清肝利胆汤 中医证候积分 炎症因子 

分 类 号：R575.6[医药卫生—消化系统]