原发性肝癌患者经导管动脉化疗栓塞术治疗后栓塞综合征的发生情况及其危险因素分析  

Analysis of the Occurrence of Embolization Syndrome and Its Risk Factors in Patients with Pulmonary Primary Liver Carcinoma after Transcatheter Arterial Chemoembolization Treatment

作　　者：苗军程 MIAO Juncheng(Department of Medical Oncology,Jinxiang County People’s Hospital,Jining 272200,China)

机构地区：[1]金乡县人民医院肿瘤内科,山东济宁272200

出　　处：《反射疗法与康复医学》2025年第5期116-119,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的 分析原发性肝癌(PLC)患者经导管动脉化疗栓塞术(TACE)治疗后栓塞综合征(PES)的发生情况及其危险因素。方法 回顾性分析2019年2月—2024年2月于金乡县人民医院行TACE治疗的64例PLC患者的临床资料,根据是否并发PES分为发生组(n=34)与未发生组(n=30)。收集两组患者的一般资料,进行单因素分析与多因素Logistic回归分析以明确PLC患者TACE术后并发PES的危险因素。结果 64例TACE后PLC患者中,34例并发PES,发生率为53.12%(34/64)。单因素分析结果显示,两组年龄、体质指数、文化水平、肿瘤直径、术前疼痛、栓塞次数、Child-Pugh分级比较,组间差异无统计学意义(P>0.05);两组性别、栓塞剂种类、巴塞罗那临床肝癌(BCLC)分期、美国东部肿瘤协作组(ECOG)评分,组间差异有统计学意义(P<0.05)。采用Logistic回归分析结果显示,栓塞剂种类为碘化油类(OR=6.662,95%CI=2.185~20.310)、ECOG评分为1分(OR=2.956,95%CI=1.052~8.307)、BCLC分期为C期(OR=0.273,95%CI=0.097~0.768)是影响TACE后PLC患者并发PES的高危险因素(P<0.05且OR>1)。结论 性别、栓塞剂种类、BCLC分期、ECOG评分均是影响PLC患者TACE后发生PES的危险因素,临床应考虑根据上述因素,制订干预措施,以改善患者预后。Objective Analysis of the occurrence of embolization syndrome and its risk factors in patients with primary liver carcinoma(PLC)pulmonary embolization syndrome(PES)after transcatheter arterial chemoembolization(TACE)treatment.Methods A retrospective analysis was conducted on the clinical data of 64 patients with PLC who underwent TACE treatment at Jinxiang County People’s Hospital from February 2019 to February 2024,according to whether they were complicated with PES or not,the patients were divided into the occurrence group(n=34)and the non-occurrence group(n=30).The general data of the patients in the two groups were collected,and univariate analysis and multivariate Logistic regression analysis were performed to identify the risk factors for PES in PLC patients after TACE.Results Among 64 PLC patients after TACE,34 cases were complicated with PES,and the incidence rate was 53.12%(34/64).The results of the univariate analysis showed that in terms of the comparison of age,body mass index,educational level,tumor diameter,preoperative pain,number of embolizations,and Child-Pugh classification between the two groups,and there was no statistically significant difference between the groups(P>0.05);the gender,type of embolic agent,Barcelona Clinic Liver Cancer(BCLC)staging,and Eastern Cooperative Oncology Group(ECOG)score between the two groups,and the differences between the two groups were statistically significant(P<0.05).The results of Logistic regression analysis showed that the types of embolic agents were lipiodol~based(OR=6.662,95%CI=2.185~20.310),the ECOG performance status score was 1 point(OR=2.956,95%CI=1.052~8.307),and the BCLC stage was stage C(OR=0.273,95%CI=0.097~0.768)were high risk factors affecting the occurrence of PES in PLC patients after TACE(P<0.05 and OR>1).Conclusion Gender,the type of embolic agent,BCLC staging,and ECOG score are all risk factors affecting the occurrence of PES in PLC patients after TACE.Clinically,it is necessary to consider formulating intervention measures according to

关 键 词：原发性肝癌 经导管动脉化疗栓塞术 栓塞综合征 危险因素 

分 类 号：R735.7[医药卫生—肿瘤]