注射用己酮可可碱联合奥扎格雷钠治疗急性脑梗死患者的临床效果  

Clinical Effect of Pentoxifylline for Injection Combined with Sodium Ozagrel in the Treatment of Patients with Acute Cerebral Infarction

作　　者：骆乐 周欣 LUO Le;ZHOU Xin(Department of Medicine and Pharmacy,Jiangning Hospital of Nanjing City,Nanjing 210000,China;Department of Neurology,JiangningHospital of Nanjing City,Nanjing 210000,China)

机构地区：[1]南京市江宁医院医药学部,江苏南京210000 [2]南京市江宁医院神经内科,江苏南京210000

出　　处：《反射疗法与康复医学》2025年第5期120-123,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的 探讨注射用己酮可可碱联合奥扎格雷钠治疗对急性脑梗死(ACI)患者神经功能的影响。方法 回顾性分析2021年5月—2024年5月南京市江宁医院收治的80例ACI患者的临床资料,按照治疗方式的不同将其分为对照组和观察组,每组40例。对照组采用常规治疗联合奥扎格雷钠治疗,观察组在对照组基础上采用注射用己酮可可碱治疗,两组均持续治疗14 d。比较两组的临床疗效、神经功能、血流动力学指标、氧化应激指标、不良反应发生情况。结果 观察组治疗总有效率为97.50%,高于对照组的77.50%,差异有统计学意义(P<0.05)。治疗后,观察组美国国立卫生研究院卒中量表评分低于对照组,差异有统计学意义(P<0.05);观察组血浆黏度、全血高切黏度、全血低切黏度、红细胞聚集指数均低于对照组,组间差异有统计学意义(P<0.05);观察组血清超氧化物歧化酶水平高于对照组,丙二醛低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 在ACI患者中采用注射用己酮可可碱联合奥扎格雷钠治疗,能改善其血流动力学指标及神经功能,调节氧化应激指标,且安全可靠。Objective To investigate the effect of pentoxifylline for injection combined with sodium ozagrel on neurological function in atients with acute cerebral infarction(ACI).Methods A retrospective analysis was conducted on the clinical data of 80 patients with ACI admitted to Jiangning Hospital of Nanjing City from May 2021 to May 2024,according to different treatment methods,they were divided into a control group and an observation group,with 40 cases in each group.The control group was treated with conventional therapy combined with sodium ozagrel,and the observation group was treated with pentoxifylline for injection on the basis of the control group,both groups were continuously treated for 14 days.The clinical efficacy,neurological function,hemodynamic indicators,oxidative stress indicators and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.50%,which was higher than 77.50%in the control group,and the difference was statistically significant(P<0.05).After treatment,the National Institutes of Health Stroke Scale score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);the plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,and red blood cell aggregation index of the observation group were all lower than those of the control group,and the difference between the groups were statistically significant(P<0.05);the level of serum superoxide dismutase in the observation group was higher than that in the control group,while the level of malondialdehyde was lower than that in the control group,and the difference between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment with pentoxifylline for injection combined with sodium ozagrel in patients with acute cerebral infarction can im

关 键 词：急性脑梗死 奥扎格雷钠 注射用己酮可可碱 血流动力学指标 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]