血清s-CD105、CA199在乳腺癌患者行改良根治术后复发转移中的预测价值  

Predictive Value of Serum s-CD105 and CA199 in Recurrence and Metastasis of Breast Cancer Patients after Modified Radical Mastectomy

作　　者：包赟 BAO Yun(Department of Oncology,The Second People’s Hospital of Taizhou City,Taizhou 225300,China)

机构地区：[1]泰州市第二人民医院肿瘤科,江苏泰州225300

出　　处：《反射疗法与康复医学》2025年第7期123-127,共5页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨血清可溶性内皮糖蛋白105(s-CD105)、糖类抗原199(CA199)在预测乳腺癌改良根治术患者术后复发转移中的价值。方法回顾性分析2018年3月—2021年3月泰州市第二人民医院120例行乳腺癌改良根治术患者的临床资料。随访3年,根据是否发生复发转移分为复发转移组(n=16)和非复发转移组(n=104),比较两组一般资料和血清s-CD105、CA199水平,分析乳腺癌改良根治术患者术后复发转移的影响因素以及血清s-CD105、CA199在预测术后复发转移中的价值。结果本研究结果显示,120例行乳腺癌改良根治术患者,16例患者术后发生复发转移,发生率为13.33%(16/120)。单因素分析结果显示,两组肿瘤分期(TNM分期)、分化程度、s-CD105、CA199、血清糖类抗原15-3(CA15-3)与乳腺癌改良根治术患者术后复发转移有关,组间差异有统计学意义(P<0.05)。Logistic回归分析结果显示,s-CD105升高、CA199升高、CA15-3升高、TNM分期Ⅲ期、分化程度低分化是影响行乳腺癌改良根治术后复发转移的高危险因素(P<0.05且OR>1)。受试者工作特征曲线绘制结果显示,血清s-CD105、CA199联合预测行乳腺癌改良根治术患者术后复发转移的曲线下面积高于两者单独预测。结论血清s-CD105、CA199能够预测乳腺癌改良根治术患者术后复发转移,且两者联合预测价值更高。Objective To explore the value of serum soluble endoglin 105(s-CD105)and carbohydrate antigen 199(CA199)in predicting postoperative recurrence and metastasis of breast cancer patients who underwent modified radical mastectomy.Methods The clinical data of 120 breast cancer patients who underwent modified radical mastectomy in the Second People’s Hospital of Taizhou City from March 2018 to March 2021 were retrospectively analyzed.The patients were followed up for 3 years.According to whether recurrence and metastasis occurred,they were divided into the recurrence and metastasis group(n=16)and the non-recurrence and metastasis group(n=104).The general data and the levels of serum s-CD105 and CA199 between the two groups were compared.The influencing factors of postoperative recurrence and metastasis in breast cancer patients after modified radical mastectomy and the value of serum s-CD105 and CA199 in predicting postoperative recurrence and metastasis were analyzed.Results The results of this study showed that among 120 breast cancer patients who underwent modified radical mastectomy,16 patients had postoperative recurrence and metastasis,with an incidence rate of 13.33%(16/120).The results of the univariate analysis showed that tumor staging(TNM staging),degree of differentiation,s-CD105,CA199,and serum carbohydrate antigen 15-3(CA15-3)were associated with postoperative recurrence and metastasis in patients who underwent modified radical mastectomy for breast cancer in the two groups,and the differences between the two groups were statistically significant(P<0.05).The results of Logistic regression analysis showed that increased s-CD105,increased CA199,increased CA15-3,TNM stage III,and low degree of differentiation were highrisk factors affecting recurrence and metastasis after modified radical mastectomy for breast cancer(P<0.05 and OR>1).The results of drawing the receiver operating characteristic curve showed that the area under the curve of the combined prediction of postoperative recurrence and metastasis i

关 键 词：乳腺癌 复发转移 改良根治术 可溶性内皮糖蛋白105 糖类抗原199 

分 类 号：R737.9.6[医药卫生—肿瘤]