固定野适形调强放疗与旋转容积调强放疗在鼻咽癌患者中的剂量学比较  

Dosimetric Comparison between Fixed-Field Intensity-Modulated Radiation Therapy and Volumetric Modulated Arc Therapy in Nasopharyngeal Carcinoma Patients

作　　者：全兴亮 洪文松[1] QUAN Xingliang;HONG Wensong(Radiation Oncology Center,The Second People’s Hospital of Guangdong Province,Guangzhou 510000,China)

机构地区：[1]广东省第二人民医院放疗中心,广东广州510000

出　　处：《反射疗法与康复医学》2025年第7期145-148,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的比较固定野适形调强(IMRT)放疗与旋转容积调强(VMAT)放疗在鼻咽癌患者治疗中的剂量学差异。方法选取广东省第二人民医院2022年1月—2023年12月收治的82例鼻咽癌患者为研究对象,按随机数字表法将其分为VMAT组和IMRT组,每组41例。VMAT组采用VMAT放疗,IMRT组采用IMRT放疗,两组均持续治疗6周。比较两组的临床疗效、治疗效率、靶区剂量、风险器官受量、不良反应发生情况。结果两组疾病缓解率比较,差异无统计学意义(P>0.05)。VMAT组加速器跳数为(650.19±107.03)MUs,少于IMRT组的(1124.27±188.05)MUs,出束时间为(1.61±0.20)min,短于IMRT组的(2.83±0.34)min,组间差异有统计学意义(P<0.05)。两组原发肿瘤体积靶区、高危亚临床靶区、低危亚临床靶区剂量比较,组间差异无统计学意义(P>0.05)。VMAT组晶体、视神经、下颌的受量均低于IMRT组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在鼻咽癌患者治疗中,采用VMAT放疗相较于采用IMRT放疗加速器跳数和出束时间更少,且在保证疗效的同时能降低晶体、视神经和下颌等风险器官的受量。Objective To compare the dosimetric differences between fixed-field intensity-modulated radiation therapy(IMRT)and volumetric modulated arc therapy(VMAT)in the treatment of nasopharyngeal carcinoma patients.Methods A total of 82 nasopharyngeal carcinoma patients admitted to the Second People's Hospital of Guangdong Province from January 2022 to December 2023 were selected as the research subjects,according to the random number table method,they were divided into a VMAT group and a IMRT group,with 41 cases in each group.The VMAT group received VMAT radiation therapy,and the IMRT group received IMRT radiation therapy,both groups were continuously treated for 6 weeks.The clinical efficacy,treatment efficiency,target volume dose,dose received by organs at risk,and the occurrence of adverse reactions were compared between the two groups.Results There was no significant difference in the disease remission rate between the two groups(P>0.05).The number of monitor units of the accelerator in the VMAT group was(650.19±107.03)MUs,which was less than(1124.27±188.05)MUs in the IMRT group,and the beam-on time was(1.61±0.20)min,which was shorter than(2.83±0.34)min in the IMRT group,and the differences between the groups were statistically significant(P<0.05).There were no significant differences in the doses of the gross tumor volume target volume,high-risk subclinical target volume,and low-risk subclinical target volume between the two groups(P>0.05).The doses received by the lens,optic nerve,and mandible in the VMAT group were all lower than those in the IMRT group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of nasopharyngeal carcinoma patients,compared with IMRT radiation therapy,VMAT radiation therapy has fewer monitor units of the accelerator and shorter beam-on time,and can reduce the doses received by organs at risk such as the lens,optic nerve,and man

关 键 词：鼻咽癌 旋转容积调强 固定野适形调强 放疗 剂量学 

分 类 号：R739.63[医药卫生—肿瘤]