NSCLC患者血清AIF-1、IL-6和VEGF水平异常变化及临床意义  

Abnormal Changes and Clinical Significance of SerumA IF-1,IL-6 and VEGF Levels in NSCLC Patients

作　　者：王玲玲 姜浩[2] 朱金伶[3] 刘瑞林 朱安军 耿学丽[1] WANG Ling-ling;JIANG Hao;ZHU Jin-ling;LIU Rui-lin;ZHU An-jun;GENG Xue-li(Clinical Laboratory,The Affiliated Hospital of Chengde Medical University,Chengde,Hebei,067000,China;Clinical Laboratory of Chengde Central Hospital,Chengde,Hebei,067000,China;Clinical Laboratory of Luanping County Hospital,Chengde,Hebei,067000,China;Clinical Laboratory of Pingquan City Hospital,Chengde,Hebei,067000,China;Cardiology department,Pingquan Hospital of Traditional Chinese Medicine,Chengde,Hebei,067000,China)

机构地区：[1]承德医学院附属医院检验科,河北承德067000 [2]承德市中心医院检验科,河北承德067000 [3]河北省滦平县医院检验科,河北承德067000 [4]平泉市医院检验科,河北承德067000 [5]平泉市中医院心内科,河北承德067000

出　　处：《承德医学院学报》2025年第2期100-106,共7页Journal of Chengde Medical University

基　　金：河北省政府资助临床医学优秀人才培养项目(ZF2024237);承德市科技计划项目(202204A073)。

摘　　要：目的研究同种异体移植炎症因子1(AIF-1)、白细胞介素6(IL-6)和血管内皮生长因子(VEGF)对非小细胞肺癌(NSCLC)诊断和预后评估的价值。方法选取183例NSCLC患者和120例健康体检者,分为NSCLC组和对照组,比较2组血清AIF-1、IL-6和VEGF的表达差异;分析其与CEA、SCCA、CYFRA21-1等肿瘤标志物及NSCLC临床病理特征的关系;应用受试者工作特征(ROC)曲线分析三者对NSCLC的诊断价值;分析血清AIF-1、IL-6、VEGF与生存的关系。结果NSCLC患者血清AIF-1、IL-6、VEGF高于健康对照组(P<0.05),与CEA、SCCA、CYFRA21-1呈正相关(P<0.05);三者与淋巴结转移、远处转移、癌组织分化程度、TNM分期有关(P<0.05),IL-6还与癌组织大小有关(P<0.05);ROC曲线分析结果显示:三者联合检测,诊断NSCLC的敏感性为0.88,特异性为0.78,曲线下面积(AUC)为0.88,95%CI为0.84-0.92,优于单一指标;生存分析显示,AIF-1和IL-6高表达组的NSCLC患者总体生存率比低表达组低,差异有统计学意义(P<0.05)。结论AIF-1、IL-6和VEGF参与了NSCLC的发生发展过程,有助于NSCLC的临床诊断和预后评估。Objective To study the value of allograft inflammatory factor 1(AIF-1),interleukin-6(IL-6)and vascular endothelial growth factor(VEGF)in the diagnosis and prognosis assessment of non-small cell lung cancer(NSCLC).Methods A total of 183 NSCLC patients and 120 healthy subjects were selected.and divided into NSCLC group and control group The expression of serum AIF-1,IL-6 and VEGF were compared between the two groups.The relationship between them and tumor markers such as CEA,SCCA,CYFRA21-1 and clinicopathological features of NSCLC was analyzed.ROC curve was employed to analyze the diagnostic value of the three factors in NSCLC.The relationship between serum AIF-1,IL-6,VEGF and survival was analyzed.Results The serum levels of AIF-1,IL-6 and VEGF in NSCLC patients were higher than those in healthy controls(P<0.05),was positively correlated with CEA,SCCA and CYFRA21-1(P<0.05).The three factors were related to lymph node metastasis,distant metastasis,tumor differentiation and TNM stage(P<0.05),IL-6 was also associated with cancer tissue size(P<0.05).ROC curve analysis showed that the sensitivity,specificity,area under the curve(AUC)and 95%CI of the three combined detection were 0.88,0.78,0.88,0.84-0.92,respectively,which were better than those of single index.Survival analysis showed that the overall survival rate of NSCLC patients with high expression of AIF-1 and IL-6 was significantly lower than that with low expression of AIF-1 and IL-6(P<0.05).Conclusion AIF-1,IL-6 and VEGF are involved in the occurrence and development of NSCLC,which are helpful for the clinical diagnosis and prognosis evaluation of NSCLC.

关 键 词：非小细胞肺癌 同种异体移植炎症因子1 白细胞介素6 血管内皮生长因子 

分 类 号：R734.2[医药卫生—肿瘤]