铁死亡在肿瘤免疫微环境中的双重角色:机遇与挑战并存  

The dual roles of ferroptosis in the tumor immune microenvironment:both opportunities and challenges

作　　者：方慧桧 张秀 洪婷 房超 蔡立 王瑛 吴娜怡园 王静 FANG Huihui;ZHANG Xiu;HONG Ting;FANG Chao;CAI Li;WANG Ying;WU Nayiyuan;WANG Jing(Graduate Collaborative Training Base of Hunan Cancer Hospital,Hengyang Medical School,University of South China,Hengyang,421001,Hunan,China;Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,410006,Hunan,China;The University of Texas MD Anderson Cancer Center,Houston,46011,Texas,U.S.A.)

机构地区：[1]南华大学衡阳医学院湖南省肿瘤医院研究生协作培养基地,湖南衡阳421099 [2]湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院,湖南长沙410006 [3]美国得克萨斯大学安德森癌症中心,得克萨斯州休斯顿46011

出　　处：《肿瘤药学》2025年第1期38-45,共8页Anti-Tumor Pharmacy

基　　金：国家自然科学基金项目(82473222);湖南省自然科学基金部门联合基金(2024JJ8132);湖南省卫生健康委科研项目(B2023047708);湖南省肿瘤医院攀登计划科研项目(2023NSFC-A003)。

摘　　要：铁死亡是一种铁依赖性脂质过氧化诱导的调节性细胞死亡形式,近年来在癌症治疗领域引起了广泛关注。免疫治疗是肿瘤治疗领域冉冉升起的新星,取得了进展性的治疗效果,但目前仍有局限性。本文深入探讨了铁死亡在肿瘤免疫微环境和抗肿瘤免疫中的双重作用,剖析了铁死亡在肿瘤免疫治疗中的临床应用潜力,为更有效和更安全的免疫治疗提供一条新策略。Ferroptosis,a form of regulated cell death induced by iron-dependent lipid peroxidation,has attracted exten⁃sive attention in the field of cancer therapy in recent years.While immunotherapy has emerged as a promising star in tumor treatment with progressive therapeutic achievements,it still faces clinical limitations.This review deeply discusses the dual roles of ferroptosis in shaping the tumor immune microenvironment and modulating anti-tumor immunity,analyzes its clini⁃cal application potential in tumor immunotherapy,and proposes a novel strategy to develop more effective and safer immu⁃notherapeutic approaches through ferroptosis regulation.

关 键 词：铁死亡 肿瘤 免疫微环境 免疫治疗 

分 类 号：R730.51[医药卫生—肿瘤]