三黄苔藓饮联合常规西药治疗脾胃湿热型糜烂型口腔扁平苔癣患者的临床效果  

Clinical Effect of Sanhuang Lichen Decoction Combined with Conventional Western Medicine on Patients with Erosive Oral Lichen Planus with Spleen and Stomach Damp-Heat Type

作　　者：荣宁 王芳 张晓莉 刘玉凤 付玉萍 RONG Ning;WANG Fang;ZHANG Xiaoli;LIU Yufeng;FU Yuping(Department of Stomatology,Shouguang Traditional Chinese Medicine Hospital,Shouguang 262700,China;Department of Pharmacy,Shouguang Traditional Chinese Medicine Hospital,Shouguang 262700,China)

机构地区：[1]寿光市中医医院口腔科,山东寿光262700 [2]寿光市中医医院药学部,山东寿光262700

出　　处：《反射疗法与康复医学》2025年第1期17-19,23,共4页Reflexology And Rehabilitation Medicine

基　　金：潍坊市中医药科学技术研究项目(WFZYY2023-4-089)。

摘　　要：目的探讨三黄苔藓饮联合常规西药在脾胃湿热型糜烂型口腔扁平苔癣(OLP)患者中的治疗效果。方法选取2022年4月—2024年4月寿光市中医医院收治的94例脾胃湿热型糜烂型OLP患者为研究对象,按随机数字表法将其分为对照组和观察组,各47例。对照组采用常规西药治疗,观察组在对照组基础上加用三黄苔藓饮治疗,两组均持续治疗3个月。对比两组的临床疗效、中医证候积分、氧化应激反应及不良反应发生情况。结果观察组治疗总有效率为95.74%,高于对照组的80.85%,差异有统计学意义(P<0.05)。治疗后,观察组中医证候积分、脂质过氧化物、丙二醛均低于对照组,超氧化物歧化酶高于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论三黄苔藓饮联合常规西药治疗脾胃湿热型糜烂型OLP患者,可增强治疗效果,有利于减轻临床症状,改善氧化应激反应及免疫水平,且未增加不良反应。Objective To explore the therapeutic effect of Sanhuang Lichen Decoction combined with conventional western medicine in the treatment of patients with erosive oral Lichen planus(OLP)with spleen and stomach damp-heat type.Methods A total of 94 patients with erosive OLP with spleen and stomach damp-heat type admitted to Shouguang Traditional Chinese Medicine Hospital from April 2022 to April 2024 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 47 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Sanhuang Lichen Decoction on the basis of the control group,both groups were treated for 3 months.The clinical efficacy,TCM syndrome score,oxidative stress reaction and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.74%,which was higher than 80.85%of the control group,and the difference was statistically significant(P<0.05).After treatment,TCM syndrome scores,lipid peroxides and malondialdehyde in observation group were lower than those in control group,and superoxide dismutase was higher than that in control group,and the differences between the groups were statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Sanhuang Lichen Decoction combined with conventional Western medicine can enhance the therapeutic effect on patients with erosive OLP with spleen and stomach damp-heat type,reduce clinical symptoms, improve oxidative stress reaction and immune level, and do not increase adverse reactions.

关 键 词：口腔扁平苔癣 糜烂型 脾胃湿热型 三黄苔藓饮 临床疗效 

分 类 号：R781.5[医药卫生—口腔医学]