龈沟液中IL-8、MMP-8和IL-6联合预测年轻恒牙根尖周病变患者IROOT-BP牙髓血运重建效果研究  

Study on the Combined Prediction of the Efficacy of IROOT-BP Pulp Revascularization in Patients with Periapical Lesions of Young Permanent Teeth by Interleukin-8,Matrix Metalloproteinase-8 and Interleukin-6 in Gingival Crevicular Fluid

作　　者：王婷 Wang Ting(Department of Stomatology,Beijing No.2 Hospital,Beijing 100031)

机构地区：[1]北京市第二医院口腔科,北京100031

出　　处：《科技与健康》2025年第3期34-36,188,共4页Technology and Health

摘　　要：分析龈沟液中白介素-8(IL-8)、基质金属蛋白酶-8(MMP-8)、白介素-6(IL-6)联合预测年轻恒牙根尖周病变患者IROOT-BP牙髓血运重建的效果。选取2021年9月—2024年3月北京市第二医院收治的87例年轻恒牙根尖周病变患者作为研究对象。针对所有患者开展IROOT-BP PR治疗,根据临床治疗效果将患者分为有效组(n=73)和无效组(n=14)。对比两组患者龈沟液中的IL-8、IL-6、MMP-8水平,分析年轻恒牙根尖周病变患者IROOT-BP牙髓血运重建效果的影响因素。多因素Logistic回归分析结果显示,龈沟液IL-8、IL-6、MMP-8水平是影响年轻恒牙根尖周病变患者IROOT-BP牙髓血运重建治疗效果的独立危险因素。研究发现,在年轻恒牙根尖周病变患者接受IROOT-BP牙髓血运重建治疗的过程中,监测龈沟液IL-8、IL-6、MMP-8水平变化有利于辅助医生调整治疗方案,优化患者的治疗效果。This study aims to analyze the combined prediction of the efficacy of IROOT-BP pulp revascularization in patients with periapical lesions of young permanent teeth by interleukin-8(IL-8),matrix metalloproteinase-8(MMP-8)and interleukin-6(IL-6)in gingival crevicular fl uid.A total of 87 patients with periapical lesions of young permanent teeth admitted to Beijing No.2 Hospital from September 2021 to March 2024 were selected as the research subjects.A half-year follow-up was carried out after the treatment,and the patients were divided into an eff ective group(n=73)and an ineff ective group(n=14)according to the clinical treatment eff ect.The levels of IL-8,IL-6 and MMP-8 in gingival crevicular fl uid of the two groups of patients were compared,and the infl uencing factors of the efficacy of IROOT-BP pulp revascularization in patients with periapical lesions of young permanent teeth were analyzed.The results of multivariate Logistic regression analysis showed that the levels of IL-8,IL-6 and MMP-8 in gingival crevicular fl uid were independent risk factors aff ecting the treatment eff ect of IROOT-BP pulp revascularization in patients with periapical lesions of young permanent teeth.The study found that during the IROOT-BP pulp revascularization treatment for patients with periapical lesions of young permanent teeth,monitoring the changes in the levels of IL-8,IL-6 and MMP-8 in gingival crevicular fl uid is benefi cial for assisting doctors in adjusting the treatment plan and optimizing the treatment eff ect of patients.

关 键 词：年轻恒牙 根尖周病变 炎症因子 牙髓血运重建术 

分 类 号：R781.42[医药卫生—口腔医学]