苦参黄芪汤联合艾迪注射液治疗原发性肝癌的效果评价  

Effect evaluation of Kushen Huangqi decoction combined with Aidi injection in the treatment of primary liver cancer

作　　者：于光华 宋春燕[2] 宋雪 YU Guanghua;SONG Chunyan;SONG Xue(Department of Pediatrics,82nd Group Military Hospital of PLA,Hengshui 071000,China;Department of Traditional Chinese Medicine,the Fourth People's Hospital of Hengshui;Department of Traditional Chinese Medicine,Hengshui Traditional Chinese Medicine Hospital)

机构地区：[1]解放军第八十二集团军医院儿科,071000 [2]衡水市第四人民医院中医科 [3]衡水市中医医院中医内科

出　　处：《天津医药》2025年第4期429-433,共5页Tianjin Medical Journal

基　　金：河北省中医药类科学研究课题计划项目(2024513)。

摘　　要：目的探讨苦参黄芪汤联合艾迪注射液治疗原发性肝癌的疗效及对免疫功能和生活质量的影响。方法纳入110例原发性肝癌患者并采用随机数字表法分为联合组55例和对照组55例。对照组在常规治疗的基础上使用艾迪注射液(50 mL),联合组在对照组基础上加用苦参黄芪汤。比较2组治疗1个月后的效果以及治疗前后生活质量[Karnofsky功能状态(KPS)评分、健康状况调查简表(SF-36)]、中医症候积分、肝功能指标[总胆红素(TBIL)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)]和免疫功能指标差异。结果治疗后,2组患者的KPS评分、SF-36评分、CD4^(+)、CD4^(+)/CD8^(+)均增加,且联合组高于对照组;2组中医症候积分、AST、TBIL、ALT和CD8^(+)均降低,且联合组低于对照组(P<0.05)。结论苦参黄芪汤联合艾迪注射液治疗原发性肝癌有利于增强患者免疫功能,降低中医症候积分和肝功能损伤,提高疗效和生活质量。Objective To investigate the therapeutic effect of Kushen Huangqi decoction combined with Aidi injection on primary liver cancer and its impacts on immune function and quality of life.Methods A total of 110 patients with primary liver cancer were randomly divided into the combined group(n=55)and the control group(n=55).The control group was treated with Aidi injection(50 mL)on the basis of routine treatment,and the combined group was treated with Kushen Huangqi decoction on the basis of the control group.The healing effects,traditional Chinese medicine(TCM)symptom scores,quality of life[Karnofsky Performance Status(KPS)score,the MOS 36-item short-form health survey(SF-36)],liver function indicators[total bilirubin(TBIL),aspartate aminotransferase(AST),alanine aminotransferase(ALT)]and immune function indicators before and after treatment were compared between the two groups.Results After treatment,the KPS score,SF-36 score,CD4^(+)and CD4^(+)/CD8^(+)were increased in the two groups,and those in the combined group were higher than the control group.The TCM symptom scores,AST,TBIL,ALT and CD8^(+)were decreased in the two groups,and those in the combined group were lower than those in the control group(P<0.05).Conclusion The combination of Kushen Huangqi decoction and Aidi injection is beneficial for enhancing immune function,reducing Chinese medicine syndrome scores and liver function damage,improving efficacy and quality of life in treating primary liver cancer.

关 键 词：艾迪注射液 药物疗法 联合 药物评价 生活质量 苦参黄芪汤 原发性肝癌 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤] R286.91[医药卫生—临床医学]