氧化应激及抗氧化剂在急性胰腺炎中的研究进展  

Research progress of oxidative stress and antioxidants in acute pancreatitis

作　　者：丁杨娟 夏时海 许威 高庆红 刘涛涛 DING Yangjuan;XIA Shihai;XU Wei;GAO Qinghong;LIU Taotao(Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Gastroenterology,Characteristic Medical Center of the Chinese People's Armed Police Force,Tianjin Key Laboratory of Liver and Pancreatic Fibrosis and Molecular Diagnosis and Treatment)

机构地区：[1]天津中医药大学研究生院,301617 [2]武警特色医学中心消化内科,天津市肝脏胰腺纤维化与分子诊疗重点实验室

出　　处：《天津医药》2025年第4期444-448,共5页Tianjin Medical Journal

基　　金：天津市卫生健康科技项目(TJWJ2023QN100);天津市科技计划项目(22JCQNJC00870)。

摘　　要：急性胰腺炎(AP)是临床常见的急腹症之一,通常为自限性,但约有20%发展为重症急性胰腺炎,以持续性全身炎症反应综合征及多器官功能障碍综合征为特征,病死率高。AP发病机制复杂,涉及多种病理生理过程,近年来,氧化应激(OS)在AP中的作用日益受到关注。OS指机体受到内外源刺激后活性氧的产生与抗氧化能力失衡,OS可导致胰腺细胞损伤、炎症反应加剧和器官功能障碍。抗氧化剂在动物模型中可减少OS引起的胰腺损伤和多器官功能障碍。该文综述了目前OS在AP中的分子机制及其在疾病进展中的作用,并总结了近年来抗氧化剂在AP治疗中的研究进展。Acute pancreatitis(AP),one of the most common acute abdominal conditions in clinical practice,is typically self-limiting.However,approximately 20%of cases progress to severe acute pancreatitis,characterized by persistent systemic inflammatory response syndrome and multiple-organ dysfunction syndrome,with a high mortality rates.The pathogenesis of AP involves complex pathophysiological processes,and in recent years,the role of oxidative stress(OS)in AP has garnered increasing attention.OS refers to an imbalance between reactive oxygen species production and antioxidant capacity following endogenous or exogenous stimuli,which can lead to pancreatic cell injury,exacerbation of inflammatory responses,and organ dysfunction.Notably,antioxidants have demonstrated efficacy in reducing OS-induced pancreatic damage and multi-organ dysfunction in animal models.This article reviews current molecular mechanisms of OS in AP,its role in disease progression and recent advances in antioxidant-based therapeutic strategies for AP.

关 键 词：胰腺炎 急性坏死性 氧化性应激 抗氧化剂 炎症 

分 类 号：R576[医药卫生—消化系统]