艾司奥美拉唑联合荜铃胃痛颗粒治疗上腹痛综合征的疗效与安全性研究  

Efficacy and safety of esomeprazole combined with Biling Weitong granules in the treatment of epigastric pain syndrome

作　　者：张颖 王业流 周淑萍 ZHANG Ying;WANG Yeliu;ZHOU Shuping(Graduate School of Bengbu Medical University,Bengbu 233030,Anhui,China;Department of Gastroenterology,the First Hospital of Anhui University of Science and Technology,Huainan 232007,Anhui,China)

机构地区：[1]蚌埠医科大学研究生院,安徽蚌埠233030 [2]安徽理工大学第一附属医院消化内科,安徽淮南232007

出　　处：《中国现代医生》2025年第10期52-54,71,共4页China Modern Doctor

摘　　要：目的探讨艾司奥美拉唑联合荜铃胃痛颗粒治疗上腹痛综合征(epigastric pain syndrome,EPS)的疗效与安全性。方法选取2024年1月至6月于安徽理工大学第一附属医院就诊的114例EPS患者,根据随机数字表法将其分为对照组和观察组,每组57例。对照组患者给予口服艾司奥美拉唑镁肠溶片,观察组患者在对照组基础上联合服用荜铃胃痛颗粒,疗程共8周。比较两组患者的外周血胃泌素-17(gastrin-17,G-17)水平、中上腹痛和/或烧灼感综合评分及不良反应发生情况。结果治疗4周和8周后,两组患者的综合评分均显著低于本组治疗前(P<0.05),观察组患者的综合评分均显著低于同期对照组(P<0.05)。治疗8周后,观察组患者的治疗有效率显著高于对照组(χ^(2)=7.600,P=0.006)。治疗8周后,两组患者的G-17水平均显著低于本组治疗前(P<0.05),且观察组患者的G-17水平显著低于对照组(P<0.05)。两组患者的不良反应发生率比较差异无统计学意义(χ^(2)=0.326,P=0.568)。结论艾司奥美拉唑联合荜铃胃痛颗粒可显著改善EPS患者的临床症状,治疗有效率更高,且安全性良好,值得临床推荐。Objective To investigate the efficacy and safety of esomeprazole combined with Biling Weitong granules in the treatment of epigastric pain syndrome(EPS).Methods A total of 114 patients with EPS treated in the First Hospital of Anhui University of Science and Technology from January to June 2024 were selected and divided into control group and observation group according to random number table method,with 57 cases in each group.The control group was given oral esomeprazole magnesium enteric-coated tablets,and the observation group was given Biling Weitong granules on the basis of control group,the courses of treatment lasted for 8 weeks.The peripheral blood gastrin-17(G-17)level,the comprehensive score of middle and upper abdominal pain and/or burning sensation and the occurrence of adverse reactions were compared between two groups.Results After 4 and 8 weeks of treatment,the comprehensive scores of two groups were significantly lower than before treatment(P<0.05),and the comprehensive scores of observation group were significantly lower than those of control group(P<0.05).After 8 weeks of treatment,the effective rate of observation group was significantly higher than that of control group(χ^(2)=7.600,P=0.006).After 8 weeks of treatment,the G-17 levels in both groups were significantly lower than before treatment(P<0.05),and the G-17 level in observation group was significantly lower than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(χ^(2)=0.326,P=0.568).Conclusion Esomeprazole combined with Biling Weitong granules is more significant in improving the clinical symptoms of EPS patients,with higher treatment efficiency and good safety,which is worthy of clinical recommendation.

关 键 词：上腹痛综合征 荜铃胃痛颗粒 艾司奥美拉唑 疗效 安全性 

分 类 号：R573[医药卫生—消化系统]