自噬与缺血性脑血管疾病的研究进展  

Research progress on autophagy and ischemic cerebrovascular diseases

作　　者：蒋萌 赵静如 刘惠 刘庆新[1] Jiang Meng;Zhao Jingru;Liu Hui;Liu Qingxin(Department of Neurology,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院神经内科,滨州256600

出　　处：《国际医药卫生导报》2025年第8期1265-1269,共5页International Medicine and Health Guidance News

基　　金：山东省医药卫生科技发展计划(2017WS157);滨州医学院科研计划与科研启动基金(BY2019KJ07)。

摘　　要：缺血性脑血管疾病(ICVD)是一种严重危害人类健康的疾病,具有发病急、致残与致死率高的特点。近年来,ICVD发病率逐年上升,且发病年龄愈发年轻化。自噬为真核生物所特有的一种自我修复过程的生命现象,是细胞内溶酶体降解吞噬物的生理过程。研究发现,缺血性脑损伤后可以激活自噬,从而影响蛋白质表达及内环境,进而加速或阻止ICVD的进程。自噬的双面性目前研究尚不明确,适度调控自噬激活可能是发挥自噬保护作用的关键。本文从ICVD、自噬相关内容及自噬在ICVD中可能的保护和损伤作用展开论述,以期为ICVD诊治提供新方案和新靶点。Ischemic cerebrovascular disease(ICVD)is a disease that seriously endangers human health,and it has the characteristics of acute onset,disability,and high mortality rate.In recent years,the incidence rate has been increasing year by year,and the age of onset is getting younger and younger.Autophagy is a life phenomenon unique to eukaryotes in self-repairing processes,and is a physiological process in which lysosomes in cells degrade phagocytoses.Studies have found that autophagy can be activated after ischemic brain injury,which affects protein expression and internal environment,thereby accelerating or stopping the progression of ICVD.The two-sided nature of autophagy is still unclear,and moderate regulation of autophagy activation may be the key to the protective role of autophagy.This article discusses the related contents of ICVD,autophagy,and the possible protective and damaging effects of autophagy in ICVD,in order to provide new solutions and targets for the diagnosis and treatment of ICVD.

关 键 词：自噬 动脉粥样硬化 信号通路 缺血性脑血管疾病 进展 

分 类 号：R743[医药卫生—神经病学与精神病学]