基于功能性近红外光谱技术探索膀胱充盈状态下的尿意相关脑功能网络  

Exploring Functional Brain Network Associated with the Urination Awareness during Bladder Filling State Based on Functional Near-infrared Spectroscopy

作　　者：施银霜 王梦寰 潘颖颖 林枫 SHI Yinshuang;WANG Menghuan;PAN Yingying;LIN Feng(School of Rehabilitation Medicine,Nanjing Medical University,Nanjing 210029,China;Department of Rehabilitation,Sir Run Run Hospital,Nanjing Medical University,Nanjing 211100,China;Department of Rehabilitation,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学康复医学院,南京210029 [2]南京医科大学附属逸夫医院康复科,南京211100 [3]南京医科大学第一附属医院康复科,南京210029

出　　处：《神经损伤与功能重建》2025年第4期192-196,219,共6页Neural Injury and Functional Reconstruction

摘　　要：目的:探索健康成人强烈尿意状态时的脑功能网络特征。方法:纳入健康受试者,分别在膀胱充盈和空虚时进行静息态功能近红外光谱技术(fNIRS)检测。应用自动解剖标记图谱(AAL)将大脑皮质分为23个感兴趣区(ROI),比较各ROI在不同状态下的氧合血红蛋白(HbO2)水平。根据各ROI的时间序列数据,建立非凸高斯图模型,图模型的边权表示功能连接强度。提取各个受试者的脑网络的骨干结构,比较同一边权在2种膀胱状态下的强度差异。最后,在每种状态下,取所有受试者时间序列数据的平均值,形成总数据用于构建图模型,继而提取骨干子网络进行可视化分析。结果:共纳入19名健康受试者。相比于膀胱充盈态,在膀胱空虚态时右侧枕上回的HbO2中位数显著偏高(P=0.0401),其余ROI未见显著差异。充盈态显著偏强的功能连接为“左眶部额中回-右眶部额下回”(P=0.0036)和“右颞极颞上回-右颞中回”(P=0.0245);空虚态显著偏强的功能连接为“左额上回-左眶部额中回”(P=0.0411)。相比于空虚态,在膀胱充盈态时额叶有更多且更强的内外功能连接,尤其是左侧额叶与右侧视听、运动和躯体感觉、扣带回-岛盖系统及腹侧颞叶联合系统的跨半球功能连接。结论:尿意相关的脑功能网络在范围上涉及额-顶系统、躯体感觉、视听系统、扣带回-岛盖系统、腹侧颞叶联合系统等多个脑网络模块,在活动模式上具有功能性暗网络特征。Objective:This research intends to explore the characteristics of functional brain networks during intense urinary states in healthy adults.Methods:Healthy subjects were included and underwent resting-state functional near-infrared spectroscopy(fNIRS)testing when the bladder was full and empty,respectively.Automatic anatomical labelling atlas(AAL)was applied to divide the cerebral cortex into 23 regions of interest(ROIs),and interstate HbO2 levels were compared for each ROI.Gaussian graphical model with nonconvex regularization was built based on the time-series data of each ROI,and the edge weights of the graphical model indicated the strength of functional connectivity(FC).The backbone structure of the brain network of each subject was extracted and used to compare the difference in strength of the same side weights in the two bladder states.Finally,in each state,the time-series data of all subjects were averaged,resulting in total data for the construction of the graph model,and then the backbone subnetworks were extracted for visualization and analysis.Results:A total of 19 healthy subjects.The median HbO2 was significantly higher in the right supraoccipital gyrus during the bladder empty state compared to the bladder full state(P=0.0401).No significant interstate differences were seen in the remaining ROIs.The FCs that were significantly stronger in the full state were“left orbital middle frontal gyrus-right orbital inferior frontal gyrus”(P=0.0036)and“right temporal pole superior temporal gyrus-right middle temporal gyrus”(P=0.0245);and the FC that was significantly stronger in the empty state was“left superior frontal gyrus-left orbital middle frontal gyrus”(P=0.0411).Compared to the empty state,the frontal lobes had more and stronger internal and external FCs during the bladder-filling state,especially the left frontal lobe’s cross-hemispheric FCs with the right audiovisual,motor and somatosensory,cingulate gyrus-insula system,and ventral temporal lobe association systems.Conclusion:The func

关 键 词：功能性近红外光谱技术 尿意 功能连接 脑网络 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R816