定量磁敏感成像在帕金森病脑铁沉积研究中的应用  

Application of Quantitative Susceptibility Mapping in the Study of Brain Iron Deposition in Parkinson's Disease

作　　者：耿敏霞 郭卫娜 陈景红[2] 李爽 邢佳豪 王天俊[2] GENG Minxia;GUO Weina;CHEN Jinghong;LI Shuang;XING Jiahao;WANG Tianjun(Graduate School of North China University of Science and Technology,Hebei Tangshan 063210,China;Department of Neurology,Hebei General Hospital,Shijiazhuang 050051,China;Department of Neurology,Baoding No.1 Central Hospital,Hebei Baoding 071028,China;Graduate School of Hebei North University,Hebei Zhangjiakou 075000,China;Graduate School of Hebei Medical University,Shijiazhuang 050031,China)

机构地区：[1]华北理工大学研究生院,河北唐山063210 [2]河北省人民医院神经内科,石家庄050051 [3]保定市第一中心医院神经内科,河北保定071028 [4]河北北方学院研究生院,河北张家口075000 [5]河北医科大学研究生院,石家庄050031

出　　处：《神经损伤与功能重建》2025年第4期211-214,245,共5页Neural Injury and Functional Reconstruction

基　　金：河北省医学科学研究课题计划(重复经颅磁刺激对帕金森病不同临床亚型患者的疗效观察,No.20230013)。

摘　　要：帕金森病(Parkinson’s disease,PD)是最常见的神经退行性疾病之一。定量磁敏感成像(quantitative susceptibility mapping,QSM)通过磁共振采集数据的无创方式使脑铁含量量化成为可能,这有助于了解铁沉积在PD发病机制中的作用,有望成为一种新型的PD生物标志物。本文通过简述基于脑内铁沉积原理的QSM在PD运动症状、非运动症状、治疗及鉴别中的研究进展,为QSM在PD及疾病早期诊断中提供了可靠的影像学依据,对PD患者病情评估及寻找新的治疗方法具有重要意义,从而为理解疾病条件下的脑铁生理学提出了一条新途径。Parkinson's disease(PD)is one of the most common neurodegenerative diseases.Quantitative Susceptibility Mapping(QSM),a non-invasive method that utilizes magnetic resonance data acquisition,makes it possible to quantify brain iron content.This helps to understand the role of iron deposition in the pathogenesis of PD and is expected to become a new type of biomarker for PD.This paper briefly describes the research progress of QSM based on the principle of intracranial iron deposition in the motor symptoms,non-motor symptoms,treatment,and differential diagnosis of PD,providing a reliable imaging basis for QSM in the early diagnosis of PD and diseases.It is of great significance for the assessment of the condition of PD patients and the search for new treatment methods,thus proposing a new approach to understanding the brain iron physiology under disease conditions.

关 键 词：帕金森病 定量磁敏感成像 铁沉积 诊断 

分 类 号：R741[医药卫生—神经病学与精神病学] R742[医药卫生—临床医学] R816