睡眠-觉醒节律紊乱与阿尔茨海默病  

Sleep-Wake Cycle Disturbances and Alzheimer's Disease

作　　者：姚宇 李墅明 刘欢 顾小萍[1,2] YAO Yu;LI Shuming;LIU Huan;GUXiaoping(Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China;Department of Anesthesiology,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,China)

机构地区：[1]南京医科大学鼓楼临床医学院,南京210008 [2]南京大学医学院附属鼓楼医院麻醉科,南京210008

出　　处：《神经损伤与功能重建》2025年第4期220-223,共4页Neural Injury and Functional Reconstruction

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种最常见的神经退行性疾病,主要临床表现为损伤性的、不可逆转的认知功能障碍。睡眠-觉醒节律紊乱是AD患者的常见症状,然而大量研究表明早在AD行为症状发生之前睡眠-觉醒节律紊乱已经存在。正常的睡眠-觉醒节律有利于β淀粉样蛋白(Amyloid-β-protein,Aβ)和tau蛋白的代谢。然而,当睡眠-觉醒周期被打乱,中枢神经系统对有害代谢物的清除就会减少。此外,睡眠-觉醒节律紊乱也可导致神经炎症和中枢神经系统氧化应激的产生,加速认知的损害。因此,本综述主要探讨睡眠-觉醒节律紊乱与AD发生发展的关系。Alzheimer’s disease(AD)is the most common neurodegenerative disease,primarily characterized by detrimental and irreversible cognitive dysfunction.Sleep-wake rhythm disturban is a common symptom in AD patients,and extensive researches have shown that sleep-wake rhythm disturban predates the onset of behavioral symptoms of AD.The normal sleep-wake rhythm facilitates the metabolism of Amyloid-β-protein(Aβ)and tau protein.However,when the sleep-wake cycle is disturbed,the central nervous system’s ability to clear harmful metabolic waste diminishes.Moreover,sleep-wake rhythm disturban can also lead to neuroinflammation and oxidative stress in the central nervous system,accelerating cognitive impairment.Therefore,this review primarily explores the relationship between the disturban of the sleep-wake cycle and the development of AD.

关 键 词：阿尔茨海默病 睡眠-觉醒节律紊乱 Β淀粉样蛋白 TAU蛋白 神经炎症 氧化应激 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R742