PI3K/AKT信号通路在多发性硬化中的作用机制研究进展  

Research Progress on the Mechanism of PI3K/AKT Signaling Pathway in Multiple Sclerosis

作　　者：李繁菊 杨雪[1] 李晓玲[2] LI Fanju;YANG Xue;LI Xiaoling(Department of Neurology,Second Hospital of Lanzhou University,Lanzhou 730000,China;Department of Rehabilitation,Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院神经内科,兰州730000 [2]兰州大学第二医院康复科,兰州730000

出　　处：《神经损伤与功能重建》2025年第4期224-228,共5页Neural Injury and Functional Reconstruction

基　　金：国家自然科学基金项目(FOXO3调控Cbl-b介导Axl泛素化促进多发性硬化自噬的机制研究,No.8236025);甘肃省中医药管理局项目(纳米姜黄素抑制铁死亡减轻EAE小鼠脱髓鞘的机制研究,No.GZKP-2022-34);甘肃省教育科技创新项目(基于FDA药物库的多发性硬化药物筛选及AXL分子保护机制研究,No.2022B-028);甘肃省科技计划项目(小脑iTBS调控缺血性脑卒中运动功能的神经网络变化机制研究,No.21JRRA359)。

摘　　要：多发性硬化(multiple sclerosis,MS)是一种自身免疫性炎症性脱髓鞘疾病。神经炎症、氧化应激、髓鞘脱失及细胞凋亡是MS重要的发病机制。磷脂酰肌醇3-激酶/蛋白激酶B(phosphatidylinositol 3-kinase/Protein Kinase B,PI3K/Akt)信号通路与上述病理生理过程密切相关。目前,针对MS的免疫抑制治疗以疾病修饰疗法为主,主要以降低复发率和短期恶化为目的,尚无法治愈该疾病,随着对MS病理机制的深入研究,新的发病机制与治疗靶点也亟待探索。本文以“多发性硬化、PI3K/Akt信号通路、炎症反应、氧化应激、细胞凋亡”为关键词,检索2004~2024年“Pubmed、中国知网、web of science”数据库中的相关文献,对PI3K/Akt信号通路与MS神经炎症,氧化应激,脱髓鞘和细胞凋亡的关系研究进展进行综述,旨在为MS的治疗提供新思路。Multiple sclerosis(MS)is an autoimmune inflammatory demyelinating disease.Neuroinflammation,oxidative stress,demyelination,and apoptosis are important pathogenesis of MS.The phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling pathway is closely related to the above pathophysiological processes.Currently,the immunosuppressive treatment for MS mainly focuses on disease-modifying therapies,aiming to reduce relapse rates and short-term exacerbations.However,it cannot cure the disease.With in-depth research into the pathological mechanism of MS,new pathogenic mechanisms and therapeutic targets urgently need to be explored.This paper takes“multiple sclerosis,PI3K/Akt signaling pathway,inflammatory response,oxidative stress,apoptosis”s keywords and retrieves relevant literature from the“Pubmed,China National Knowledge Infrastructure,and Web of Science”databases between 2004 and 2024.It reviews the research progress on the relationship between the PI3K/Akt signaling pathway and MS neuroinflammation,oxidative stress,demyelination,and apoptosis,aiming to provide new ideas for the treatment of MS.

关 键 词：多发性硬化 PI3K/AKT信号通路 炎症反应 氧化应激 细胞凋亡 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R742