代谢相关脂肪性肝病对急性胰腺炎严重程度的影响  

Influence of Metabolic Associated Fatty Liver Disease on the Severity of Acute Pancreatitis

作　　者：吴倩格 吴克俭 WU Qiange;WU Kejian(The First Clinical Medical College of Xuzhou Medical University,Jiangsu 221000,China)

机构地区：[1]徐州医科大学第一临床医学院,221000 [2]徐州医科大学附属医院消化内科,221000

出　　处：《医学研究杂志》2025年第3期152-157,共6页Journal of Medical Research

摘　　要：目的研究代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)与急性胰腺炎(acute pancreatitis,AP)之间的关系,探讨MAFLD对AP病情严重程度的影响。方法回顾性分析2021年1月~2023年3月徐州医科大学附属医院收治的526例AP患者的病例资料,采用2012年修订版Atlanta分级、急性胰腺炎严重程度床边指数(bedside index for severity in acute pancreatitis,BISAP)评分和改良CT严重指数(modified CT severity index,MCTSI)评分评估AP的严重程度。根据患者是否合并MAFLD将其分为MAFLD组(n=294)和non-MAFLD组(n=232)。比较两组患者的一般资料、实验室指标、严重程度、并发症以及住院时长等,并采用单因素和多因素Logistic回归分析评估影响AP严重程度的危险因素。结果MAFLD组患者中重症急性胰腺炎(moderately severe acute pancreatitis,MSAP)和重症急性胰腺炎(severe acute pancreatitis,SAP)的发生率更高,其BISAP评分、MCTSI评分、局部和全身并发症发生率以及重症监护率均高于non-MAFLD组患者,重症监护室的住院时间和总住院时长也长于non-MAFLD组患者。多因素Logisitc回归分析结果显示,MAFLD是MSAP和SAP发生的独立危险因素。结论MAFLD会增加AP发生的风险。合并MAFLD患者发生MSAP和SAP的风险更高,发生局部和全身并发症的风险也更高。Objective To investigate the influence of metabolic associated fatty liver disease(MAFLD)on the severity of acute pancreatitis(AP)by exploring the relationship between them.Methods The clinical data of 526 AP patients who were admitted to the Affiliated Hospital of Xuzhou Medical University from January 2021 to March 2023 were retrospectively analyzed.The severity of AP was assessed by the revised Atlanta classification,bedside index for severity in acute pancreatitis(BISAP)score,and modified CT severity index(MCTSI)score.The patients were divided into MAFLD group(n=294)and non-MAFLD group(n=232)according to the presence or absence of MAFLD.The two groups were compared in terms of the the indices such as general data,laboratory indicators,severity,complications,the length of hospital stay.Univariate and multivariate Logistic regression analysis were also used to screen the independent risk factors for the severity of AP.Results The incidence of moderately severe acute pancreatitis(MSAP)and severe acute pancreatitis(SAP)in MAFLD group were higher than those in non-MAFLD group,the BISAP score,MCTSI score,the incidence of local and systemic complications and.the duration of hospitalization and hospital stay in ICU for patients in MAFLD were also higher than those in non-MAFLD.Multivariable Logistic regression analysis showed that MAFLD was an independent risk factor for MSAP and SAP.Conclusion MAFLD increases the risk of AP.The presence of MAFLD portends a higher risk of MSAP and SAP,as well as higher incidence of local and systemic complications.

关 键 词：代谢相关脂肪性肝病 急性胰腺炎 严重度 

分 类 号：R575[医药卫生—消化系统]